| Gene Symbol | VPS11 |
| Full Name | Vacuolar Protein Sorting 11 |
| Chromosome | 11p15.5 |
| Function | VPS11 (Vacuolar Protein Sorting 11) is a core component of the HOPS (Homotypic fusion and Vacuole Protein Sorting) complex, which mediates late endosome-lysosome and autophagosome-lysosome fusion. |
| Pathways | Autophagy, autophagy pathway |
| UniProt ID | [Q9Y5G6](https://www.uniprot.org/uniprot/Q9Y5G6) |
| Ensembl ID | ENSG00000160602 |
| GeneCards | VPS11 |
| Human Protein Atlas | VPS11 |
| Endosome-lysosome fusion | Mediates trafficking to lysosomes |
| Autophagosome-lysosome fusion | Essential for autophagy completion |
| Lysosomal nutrient sensing | Links nutrient status to degradation |
| Lysosomal dysfunction | HOPS defects impair α-synuclein clearance |
| Genetic associations | VPS11 variants in PD patients |
| Autophagy impairment | Similar to PD mechanisms[@mehta2021] |
| Associated Diseases | Ms, Parkinson |
| Interactions | Akt, AKT1, AUTOPHAGY, prM |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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