concept

HUMAN GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUMAN GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

1Analyses

18Outgoing

19Incoming

0Experiments

2Debates

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💡 Concept Info

Name	HUMAN GENES
Key Genes/Proteins	AND, ASTROCYTE, ASTROCYTES, AUTOPHAGY, BRAIN INJURY, GAIN
Related Diseases	ALS, Alzheimer's Disease, Carcinoma
Related Pathways	Autophagy, Mitophagy

Pathway Diagram

graph TD
    HUMAN_GENES["HUMAN GENES"]
    HUMAN_GENES -->|"risk_factor_for"| Alzheimer_s_Disease["Alzheimer's Disease"]
    HUMAN_GENES -->|"activates"| ALS["ALS"]
    HUMAN_GENES -->|"activates"| Tumor["Tumor"]
    HUMAN_GENES -->|"activates"| Carcinoma["Carcinoma"]
    HUMAN_GENES -->|"activates"| Neurodegeneration["Neurodegeneration"]
    HUMAN_GENES -->|"activates"| VDAC2["VDAC2"]
    HUMAN_GENES -->|"activates"| TMX2["TMX2"]
    HUMAN_GENES -->|"activates"| Oxidative_Stress["Oxidative Stress"]
    PER["PER"] -->|"activates"| HUMAN_GENES
    PAP["PAP"] -->|"activates"| HUMAN_GENES
    GENES["GENES"] -->|"activates"| HUMAN_GENES
    AND["AND"] -->|"activates"| HUMAN_GENES
    PRKN["PRKN"] -->|"activates"| HUMAN_GENES
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| HUMAN_GENES
    TFEB["TFEB"] -->|"activates"| HUMAN_GENES
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| HUMAN_GENES

Outgoing (18)

Target	Relation	Type	Str
Alzheimer's Disease	risk_factor_for	disease	0.90
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Autophagy	activates	pathway	0.60
VDAC2	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
TMX2	activates	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
GAIN	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
T Cell	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (19)

Source	Relation	Type	Str
GUAGGG motif	occurs_in	gene	0.90
PER	activates	gene	0.60
PAP	activates	gene	0.60
GENES	activates	gene	0.60
AND	activates	gene	0.60
PRKN	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
TFEB	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
GAIN	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
AND	associated_with	gene	0.60
ASTROCYTES	activates	gene	0.60
NEURON	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cas13 gRNA Design for Silencing MAPT (Tau) Transcripts in Alzheimer's Disease

neurodegeneration | 2026-04-16 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Can optimized Cas13 guide RNAs selectively silence pathogenic MAPT splice varian

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Is Cas13-based 4R-tau silencing feasible given collateral cleavage risks in post

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning HUMAN GENES in their description or question text

No additional research found