gene 2,450 words KG: STXBP3
Contents

STXBP3 Gene

🧬 Gene Info
Gene SymbolSTXBP3
Chromosome19p13.3
Functionis a member of the STXBP (Syntaxin Binding Protein) family and belongs to the SM (Sec1/Munc18) protein family.
Subcellular Localization## Normal Biological Functions
Molecular Weight66 kDa
Amino Acids594 aa
Exons16
GeneCardsSTXBP3
Human Protein AtlasSTXBP3
PhosphorylationSerine/threonine phosphorylation modulates syntaxin binding
PalmitoylationAffects membrane association
UbiquitinationTargets STXBP3 for degradation
SumoylationAlters subcellular localization
Associated DiseasesAls, Alzheimer
InteractionsALZHEIMER, APOE, APP, CALB1, CCT4, COPA
KG Connections65 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (18)

s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40

See Also (12)

Genes
index · KG edge: associated_with
CALB1 (Calbindin 1)
gene · KG edge: associated_with
cct4
gene · KG edge: associated_with
IDS — Iduronate Sulfatase
gene · KG edge: associated_with
PRDX3 — Peroxiredoxin 3
gene · KG edge: associated_with

Knowledge Graph (12 edges)

IDS associated_with STXBP3
SYNCRIP associated_with STXBP3
SSBP1 associated_with STXBP3
PRDX3 associated_with STXBP3
APP associated_with STXBP3
APOE associated_with STXBP3
SYNE2 associated_with STXBP3
SMARCB1 associated_with STXBP3
ULK2 associated_with STXBP3
TMEM59 associated_with STXBP3

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