| Gene Symbol | POLD1-PROTEIN |
| Aliases | POLD1_PROTEIN |
| Function | is a heterotrimer consisting of POLD1 (catalytic subunit), POLD2 (regulatory subunit), and POLD3 (accessory subunit). |
| Subcellular Localization | Nucleus (replication foci), Mitochondria |
| Molecular Weight | ~124 kDa |
| GeneCards | POLD1-PROTEIN |
| Human Protein Atlas | POLD1-PROTEIN |
| DNA polymerase activity | Synthesizes DNA in the 5' to 3' direction using dNTPs |
| 3' → 5' exonuclease activity | Provides proofreading capability for high-fidelity replication |
| 5' → 5' exonuclease activity | Processes Okazaki fragments during lagging strand synthesis |
| strand displacement activity | Involved in long-patch DNA repair |
| N-terminal domain | Contains the proofreading exonuclease domain (POLD1 residues 1-327) |
| C-terminal domain | Contains the polymerase active site (POLD1 residues 328-1107) |
| PIP box motif | PCNA-interacting peptide for processive DNA synthesis |
| 金属离子结合位点 | Conserved aspartate residues coordinate Mg²⁺ ions for catalysis |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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