gene

PEX14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PEX14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

18Outgoing

12Incoming

0Experiments

0Debates

Summary

PEX14 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, regulates. Associated with Als, Inflammation, Ms. Connected to 22 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PEX14
Full Name	Peroxisome Biogenesis Factor 14
Chromosome	1p36.22
Protein Family	PEX proteins, peroxisomal import machinery
Function	encodes a critical component of the peroxisomal import machinery—the docking receptor for matrix proteins entering the peroxisome lumen.
Primary Expression	most tissues:
Subcellular Localization	Peroxisomal membrane
Amino Acids	377 aa
UniProt ID	Q15818
NCBI Gene ID	5195
Ensembl ID	ENSG00000134001
OMIM	603714
GeneCards	PEX14
Human Protein Atlas	PEX14
Associated Diseases	Inflammation, Parkinson
Interactions	LC3, OPTN
KG Connections	30 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PEX14 — AlphaFold Q15818 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PEX14 (Peroxisome Biogenesis Factor 14)

gene · 1127 words

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Pathway Diagram

graph TD
    PEX14["PEX14"]
    Als{"Als"}
    PEX14 -->|"interacts with"| Als
    Ms{"Ms"}
    PEX14 -->|"interacts with"| Ms
    LC3["LC3"]
    PEX14 -->|"regulates"| LC3
    Mitophagy(["Mitophagy"])
    PEX14 -->|"interacts with"| Mitophagy
    Autophagy(["Autophagy"])
    PEX14 -->|"interacts with"| Autophagy
    neurodegeneration["neurodegeneration"]
    PEX14 -->|"implicated in"| neurodegeneration
    OPTN["OPTN"]
    OPTN -->|"interacts with"| PEX14
    style PEX14 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (18)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.70
Ms	interacts_with	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	interacts_with	disease	0.65
VEGFA	associated_with	gene	0.60
Mitophagy	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
INFLAMMATION	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Complement	associated_with	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
LC3	regulates	gene	0.60
CXCR4	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60

Incoming (12)

Source	Relation	Type	Str
ATF6	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
CXCR4	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
LAMP1	expressed_in	gene	0.60
LAMP1	biomarker_for	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
OPTN	interacts_with	gene	0.60
OPTN	associated_with	gene	0.60
LC3	inhibits	gene	0.60
OPTN	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PEX14 in their description or question text

No additional research found