gene

NFATC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFATC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

21Outgoing

12Incoming

0Experiments

0Debates

Summary

NFATC2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NFATc2 / NFATC2
Aliases	NFATC2
Chromosome	20q13.12
Protein Type	Transcription Factor
Function	is a member of the NFAT (Nuclear Factor of Activated T cells) transcription factor family involved in calcium-dependent gene regulation.
Subcellular Localization	and protein interactions
Amino Acids	925 aa
Pathways	cascade: [@crabtree2001]
UniProt ID	Q13469
NCBI Gene ID	4778
Associated Diseases	neurodegeneration
Interactions	AKT, AURKA, AUTOPHAGY, CANCER, CTSB, LC3
KG Connections	33 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFATC2 — AlphaFold Q13469 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NFATc2 — Nuclear Factor of Activated T Cells 2

gene · 1544 words

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Pathway Diagram

graph TD
    NFATC2["NFATC2"]
    Cancer{"Cancer"}
    NFATC2 -->|"activates"| Cancer
    Als{"Als"}
    NFATC2 -->|"activates"| Als
    Neuroinflammation{"Neuroinflammation"}
    NFATC2 -->|"regulates"| Neuroinflammation
    Inflammation{"Inflammation"}
    NFATC2 -->|"regulates"| Inflammation
    Parkinson{"Parkinson"}
    NFATC2 -->|"regulates"| Parkinson
    Ms{"Ms"}
    NFATC2 -->|"regulates"| Ms
    NFATC2 -->|"regulates"| Als
    CTSB["CTSB"]
    NFATC2 -->|"activates"| CTSB
    Autophagy(["Autophagy"])
    NFATC2 -->|"activates"| Autophagy
    Angiogenesis(["Angiogenesis"])
    NFATC2 -->|"activates"| Angiogenesis
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NFATC2 -->|"regulates"| NEUROINFLAMMATION
    AND["AND"]
    NFATC2 -->|"regulates"| AND
    GENES["GENES"]
    NFATC2 -->|"regulates"| GENES
    MICROGLIA["MICROGLIA"]
    NFATC2 -->|"activates"| MICROGLIA
    IFN["IFN"]
    NFATC2 -->|"regulates"| IFN

Outgoing (21)

Target	Relation	Type	Str
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Parkinson	regulates	disease	0.65
IFN	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
T Cell	regulates	cell_type	0.60
Microglia	activates	cell_type	0.60
Pericyte	regulates	cell_type	0.60
Endothelial	regulates	cell_type	0.60
CTSB	activates	gene	0.60
Interferon	regulates	protein	0.60
Autophagy	activates	pathway	0.60
Angiogenesis	activates	pathway	0.60
NEUROINFLAMMATION	regulates	gene	0.60
AND	regulates	gene	0.60
GENES	regulates	gene	0.60
MICROGLIA	activates	gene	0.60

Incoming (12)

Source	Relation	Type	Str
AUTOPHAGY	activates	gene	0.60
CANCER	activates	gene	0.60
PARKINSON	regulates	gene	0.60
IFN	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
RNA	regulates	gene	0.60
PI3K	activates	gene	0.60
TPX2	activates	gene	0.60
LC3	activates	gene	0.60
AURKA	activates	gene	0.60
AKT	activates	gene	0.60
VEGFA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NFATC2 in their description or question text

No additional research found