biomarker 965 words KG: NEUROGRANIN
Contents

Neurogranin (Ng) - Synaptic Biomarker

🔬 Protein Info
Gene SymbolNEUROGRANIN
FunctionNeurogranin is essential for synaptic plasticity through
PathwaysCalcium signaling, Amyloid, Blood-Brain Barrier
GeneCardsNEUROGRANIN
Human Protein AtlasNEUROGRANIN
Cognitive DeclineHigher CSF Ng predicts faster cognitive decline
Synaptic LossCorrelates with synaptic protein loss in AD brain
Disease ProgressionIncreases with disease severity
Diagnostic UtilityHelps differentiate AD from other dementias
Synaptic ProtectionStrategies to preserve synaptic integrity may lower CSF Ng
Drug DevelopmentNg levels used as biomarker in clinical trials
Patient StratificationHigh CSF Ng identifies patients with active synaptic loss
Associated DiseasesAls, Alzheimer, Neuroinflammation
InteractionsBDNF
KG Connections61 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (28)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Flotillin-1 Stabilization Compounds
Score: 0.68
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
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Related Analyses (16)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (7)

Neurofilament Light Chain (NfL) in Blood - Biomarker
biomarker · KG edge: biomarker_for
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
BACE1 (Redirect)
redirect · KG edge: biomarker_for
GFAP (Redirect)
redirect · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with

Knowledge Graph (12 edges)

NFL biomarker_for NEUROGRANIN
BACE1 biomarker_for NEUROGRANIN
SYNAPTOPHYSIN biomarker_for NEUROGRANIN
NEUROGRANIN biomarker_for TAU
NEUROGRANIN biomarker_for SYNAPTOPHYSIN
NEUROGRANIN biomarker_for NFL
NEUROGRANIN biomarker_for BACE1
TREM2 biomarker_for NEUROGRANIN
SIGMA1 therapeutic_target NEUROGRANIN
SIGMA1 biomarker_for NEUROGRANIN

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