gene

SIGMA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIGMA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

20Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for SIGMA1 Gene

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🧬 Gene Info

Gene Symbol	SIGMA1 (SIGMAR1)
Full Name	Sigma Non-Opioid Intracellular Receptor 1
Chromosome	9p13.3
Protein Type	Chaperone
Function	The Sigma-1 receptor exhibits diverse biological functions
Primary Expression	Endoplasmic reticulum, plasma membrane, mitochondria-associated membranes
Molecular Weight	25 kDa
Amino Acids	223 aa
Gene Type	Protein coding
UniProt ID	Q99720
NCBI Gene ID	10280
Ensembl ID	ENSG00000147955
OMIM	601978
Associated Diseases	disease, Neurodegenerative Diseases
KG Connections	23 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SIGMA1 — AlphaFold Q99720 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SIGMA1 Gene

gene · 706 words

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Pathway Diagram

graph TD
    SIGMA1["SIGMA1"]
    Alzheimer{"Alzheimer"}
    SIGMA1 -->|"therapeutic_target"| Alzheimer
    Neuroinflammation{"Neuroinflammation"}
    SIGMA1 -->|"therapeutic_target"| Neuroinflammation
    Inflammation{"Inflammation"}
    SIGMA1 -->|"biomarker_for"| Inflammation
    NEUROGRANIN(["NEUROGRANIN"])
    SIGMA1 -->|"therapeutic_target"| NEUROGRANIN
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"therapeutic_target"| SIGMA1
    TREM2(["TREM2"])
    TREM2 -->|"therapeutic_target"| SIGMA1
    style SIGMA1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (20)

Target	Relation	Type	Str
Alzheimer	biomarker_for	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Neuron	therapeutic_target	cell_type	0.60
ALZHEIMER	therapeutic_target	gene	0.60
Α-Synuclein	therapeutic_target	protein	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
NEUROGRANIN	therapeutic_target	gene	0.60
NEUROGRANIN	biomarker_for	gene	0.60
TREM2	biomarker_for	gene	0.60
TREM2	therapeutic_target	gene	0.60
Neuron	expressed_in	cell_type	0.55
Neurodegenerative Diseases	associated_with	disease	0.50
disease	associated_with	disease	0.50
NEURONS	associated_with	concept	0.50

Incoming (3)

Source	Relation	Type	Str
TREM2	therapeutic_target	gene	0.60
NEUROGRANIN	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SIGMA1 in their description or question text

No additional research found