gene

MIEF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MIEF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

17Outgoing

12Incoming

0Experiments

0Debates

Summary

MIEF2 encodes MiD50, a mitochondrial outer membrane protein that recruits Drp1 to regulate mitochondrial fission. Dysfunction contributes to Parkinson's disease, Alzheimer's disease, and other neurodegenerative conditions through impaired mitochondrial dynamics and mitophagy.

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🧬 Gene Info

Gene Symbol	MIEF2
Full Name	Mitochondrial Elongation Factor 2 (MiD50)
Chromosome	17p13.1
Function	encodes a critical mitochondrial outer membrane protein that plays essential roles in regulating mitochondrial dynamics.
Molecular Weight	50 kDa
Pathways	Autophagy, Mitophagy
UniProt ID	[Q8N5Z0](https://www.uniprot.org/uniprot/Q8N5Z0)
Ensembl ID	ENSG00000146070
GeneCards	MIEF2
Human Protein Atlas	MIEF2
Transmembrane domain	Anchors protein in the outer membrane
Cytosolic domain	Interacts with Drp1 and other proteins
Flexible linker region	Connects membrane and cytosolic domains
PINK1 phosphorylation	Upon mitochondrial damage, PINK1 accumulates on the outer membrane
Parkin recruitment	PINK1 phosphorylates ubiquitin and Parkin, activating it
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	29 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MIEF2 — Mitochondrial Elongation Factor 2 (MiD50)

gene · 1575 words

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Pathway Diagram

graph TD
    MIEF2["MIEF2"]
    Obesity{"Obesity"}
    MIEF2 -->|"regulates"| Obesity
    Cancer{"Cancer"}
    MIEF2 -->|"regulates"| Cancer
    Diabetes{"Diabetes"}
    MIEF2 -->|"regulates"| Diabetes
    Cardiovascular{"Cardiovascular"}
    MIEF2 -->|"regulates"| Cardiovascular
    Ms{"Ms"}
    MIEF2 -->|"regulates"| Ms
    PINK1["PINK1"]
    MIEF2 -->|"regulates"| PINK1
    CANCER["CANCER"]
    MIEF2 -->|"regulates"| CANCER
    AND["AND"]
    MIEF2 -->|"regulates"| AND
    FXN["FXN"]
    MIEF2 -->|"regulates"| FXN
    MITOPHAGY["MITOPHAGY"]
    MIEF2 -->|"regulates"| MITOPHAGY
    AUTOPHAGY["AUTOPHAGY"]
    MIEF2 -->|"regulates"| AUTOPHAGY
    MITOCHONDRIA["MITOCHONDRIA"]
    MIEF2 -->|"regulates"| MITOCHONDRIA
    C_MYC["C-MYC"]
    MIEF2 -->|"regulates"| C_MYC
    MFN1["MFN1"]
    MIEF2 -->|"regulates"| MFN1
    FIS1["FIS1"]
    MIEF2 -->|"regulates"| FIS1

Outgoing (17)

Target	Relation	Type	Str
Cancer	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Ms	regulates	disease	0.65
Obesity	regulates	disease	0.65
C-MYC	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mitophagy	regulates	pathway	0.60
PINK1	regulates	gene	0.60
FXN	regulates	gene	0.60
MFN1	regulates	gene	0.60
CANCER	regulates	gene	0.60
FIS1	regulates	gene	0.60
AND	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60

Incoming (12)

Source	Relation	Type	Str
LYSOSOME	regulates	gene	0.60
NAD	regulates	gene	0.60
MYC	regulates	gene	0.60
DRP1	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TFEB	regulates	gene	0.60
TFAM	regulates	gene	0.60
CALCINEURIN	regulates	gene	0.60
NRF1	regulates	gene	0.60
BNIP3	regulates	gene	0.60
SIRT1	regulates	gene	0.60
MFN2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MIEF2 in their description or question text

No additional research found