concept

BLOOD-BRAIN BARRIER DISRUPTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BLOOD-BRAIN BARRIER DISRUPTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections

1Hypotheses

1Analyses

36Outgoing

46Incoming

0Experiments

1Debates

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💡 Concept Info

Name	BLOOD-BRAIN BARRIER DISRUPTION
Key Genes/Proteins	FUS, MFSD2A, VEGF
Related Diseases	NEUROINFLAMMATION, STROKE
Related Pathways	AMPK PATHWAY

Pathway Diagram

graph TD
    BLOOD_BRAIN_BARRIER_DISRUPTION["BLOOD-BRAIN BARRIER DISRUPTION"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Neuroinflammation["Neuroinflammation"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"contributes to"| Multiple_Sclerosis["Multiple Sclerosis"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Central_Nervous_System_Damage["Central Nervous System Damage"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Cognitive_Impairment["Cognitive Impairment"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"contributes to"| Neurodegenerative_Diseases["Neurodegenerative Diseases"]
    TREM1["TREM1"] -->|"mediates"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Sepsis["Sepsis"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Ischemic_Stroke["Ischemic Stroke"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Tight_Junctions["Tight Junctions"] -->|"involved_in"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Methamphetamine["Methamphetamine"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Stroke["Stroke"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    TREM1_Inhibition["TREM1 Inhibition"] -.protects against.-> BLOOD_BRAIN_BARRIER_DISRUPTION
    Hypoxia["Hypoxia"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION

Outgoing (36)

Target	Relation	Type	Str
Brain Arteriovenous Malformations	associated_with	disease	0.95
Increased Permeability	causes	phenotype	0.95
Long COVID-Associated Brain Fog	causes	disease	0.95
Neuroinflammation	causes	process	0.92
Stroke	contributes_to	disease	0.91
Neuroinflammation	mediates	process	0.90
Central Nervous System Diseases	contributes_to	disease	0.90
NEUROINFLAMMATION	causes	process	0.90
Multiple Sclerosis	associated_with	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
Chronic Inflammation	contributes_to	process	0.90
Traumatic Brain Injury	associated_with	disease	0.90
Central Nervous System Damage	causes	disease	0.85
Brain Hemorrhage	causes	disease	0.85
Neurodegenerative Diseases	contributes_to	disease	0.85
Neurological Sequelae	contributes_to	phenotype	0.85
Neurodegenerative Diseases	biomarker_for	disease	0.85
Glymphatic Dysfunction	exacerbates	mechanism	0.85
Cognitive Impairment	causes	phenotype	0.85
Neuroinflammation	associated_with	process	0.85
Brain Injury	contributes_to	process	0.85
neurodegeneration	promotes	phenotype	0.85
Neuroinflammatory Cascades	contributes_to	process	0.85
Brain Hemorrhage	contributes_to	disease	0.80
Bleeding Risk	contributes_to	phenotype	0.80
neuroinflammation	promotes	process	0.80
Parkinson's Disease	contributes_to	disease	0.80
Alzheimer's Disease	contributes_to	disease	0.75
NEUROINFLAMMATION	inhibits	phenotype	0.65
ENDOTHELIAL CELLS	regulates	cell_type	0.65
AMPK PATHWAY	associated_with	pathway	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
PREFRONTAL CORTEX	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
WHITE MATTER	associated_with	brain_region	0.45
EMPAGLIFLOZIN	associated_with	drug	0.45

Incoming (46)

Source	Relation	Type	Str
Ischemic Stroke	causes	disease	0.95
Sepsis	causes	disease	0.95
M2 Microglia-Targeting Lipid Nanoparticle	treats	drug	0.90
Tight Junction Damage	contributes_to	mechanism	0.90
Stroke	causes	disease	0.90
Tight Junctions	involved_in	process	0.90
Methamphetamine	causes	drug	0.90
Hypoxia	causes	process	0.90
TIGHT JUNCTION PROTEINS	mediates	protein	0.90
35361905	is a hallmark of	paper	0.90
AQP4 Autoantibodies	causes	biomarker	0.90
Sustained Systemic Inflammation	contributes_to	process	0.90
33381913	results in	paper	0.90
MICROGLIA	regulates	cell_type	0.90
TREM1 Inhibition	protects_against	mechanism	0.90
A1AR Ablation	protects_against	mechanism	0.90
CAV1	contributes_to	protein	0.87
Autophagy Inhibition	associated_with	process	0.87
CLDN5	involved_in	gene	0.85
CD40L	mediates	protein	0.85
APOE	involved_in	protein	0.85
Microglia Polarization	modulates	process	0.85
M2 Microglia	protects_against	cell_type	0.85
Tight Junction Damage	causes	mechanism	0.85
Complement System	promotes	pathway	0.85
EXTRACELLULAR HMGB1	causes	protein	0.85
Complement System	contributes_to	pathway	0.85
tight junctions	contributes_to	process	0.85
APOE	contributes_to	protein	0.82
mRNA nanoparticles	ameliorates	compound	0.80
CLDN5	biomarker_for	protein	0.80
AQP4	associated_with	protein	0.80
COVID-19	causes	disease	0.80
ZFPs	promotes	protein	0.80
ASPARAGINE ENDOPEPTIDASE	involved_in	enzyme	0.75
neuroinflammation	activates	process	0.70
APOE4	causes	gene	0.70
EMPAGLIFLOZIN	inhibits	drug	0.65
MFSD2A	inhibits	gene	0.65
MICROGLIA	treats	cell_type	0.65
STROKE	treats	disease	0.65
VEGF	regulates	gene	0.65
ASTROCYTE	interacts_with	cell_type	0.65
STROKE	inhibits	disease	0.65
FUS	regulates	gene	0.65
AMPK	protects_against	protein	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Blood-Brain Barrier Disruption Enabling Peripheral Inflammat	0.430	neurodegeneration	How does APOE4 mechanistically increase

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does APOE4 mechanistically increase TDP-43 pathology frequency in Alzheimer'

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.580

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract identifies APOE4 association with increased TDP-43 pathology but th

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

Related Research

Hypotheses and analyses mentioning BLOOD-BRAIN BARRIER DISRUPTION in their description or question text

No additional research found