Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about neuroinflammatory cascade: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| ischemic stroke | associated_with | disease | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro | 0.613 | neurodegeneration | What are the mechanisms by which gut mic |
| P2RX7-PANX1 Channel Blockade for Neuroinflammatory Cascade I | 0.105 | neurodegeneration | Neuroinflammation Biomarker Panel for Ea |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.919
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| AGE-mediated HCC induction in animal models with β-catenin signaling | validation | Hepatocellular carcinoma | 0.900 | 0.00 | animal models (species not spe | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Decoding cell death signals in liver inflammation. [PMID:23567086] | Brenner C, Galluzzi L, Kepp O, Kroemer G | J Hepatol | 2013 | 1 |
| Wnt-dependent modulation of alveolar epithelial phenotypes and barrier function [PMID:41678947] | Lin YC, Igarashi M, Sakai Y, Nishikawa M | Biochem Biophys Res Commun | 2026 | 0 |
| Luteolin targets the AGE-RAGE signaling to mitigate inflammation and ferroptosis [PMID:38917486] | Zhang N, Chen P, Liang X, Sun J, Liu Q, | Aging | 2024 | 0 |
| Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic li [PMID:38297127] | Fan W, Adebowale K, Váncza L, Li Y, Rabb | Nature | 2024 | 0 |
| Receptors for Advanced Glycation End Products (RAGE): Promising Targets Aiming a [PMID:36154605] | ["Koerich S", "Parreira G", "de Almeida | Current neuropharmacology | 2023 | 0 |
| Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR [PMID:37442582] | Strickson S, Houslay KF, Negri VA, Ohne | The European respiratory journ | 2023 | 0 |
| Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1 [PMID:34130712] | ["MacLean M", "Juranek J", "Cuddapah S", | Journal of neuroinflammation | 2021 | 0 |
| Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425] | Lieberwirth JK, Joset P, Heinze A, Hents | European journal of human gene | 2021 | 0 |
| Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174] | Liu J, Xie J | International journal of envir | 2020 | 0 |
| Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582] | Karas M, Marinsek N, Goldhahn J, Foschin | Digital biomarkers | 2020 | 0 |
| Glycation & the RAGE axis: targeting signal transduction through DIAPH1. [PMID:27967251] | ["Shekhtman A", "Ramasamy R", "Schmidt A | Expert review of proteomics | 2017 | 0 |
| The AGE-RAGE Axis: Implications for Age-Associated Arterial Diseases. [PMID:29259621] | ["Senatus L", "Schmidt A"] | Frontiers in genetics | 2017 | 0 |
| Diabetes and Alzheimer's disease crosstalk. [PMID:26969101] | Baglietto-Vargas D, Shi J, Yaeger DM, Ag | Neuroscience and biobehavioral | 2016 | 0 |
| Pathophysiological Links Among Hypertension and Alzheimer's Disease. [PMID:26054481] | Carnevale D, Perrotta M, Lembo G, Trimar | High blood pressure & cardiova | 2016 | 0 |
| High-fructose intake as risk factor for neurodegeneration: Key role for carboxy [PMID:26851500] | ["Mastrocola R", "Nigro D", "Cento A", " | Neurobiology of disease | 2016 | 0 |
| [Receptor of advanced glycation endproducts RAGE/AGER: an integrative view for c [PMID:25486663] | Barbezier N, Tessier FJ, Chango A | Annales de biologie clinique | 2014 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.76 · 2026-04-23
closed · Rounds: 7 · Score: 0.87 · 2026-04-16
Hypotheses and analyses mentioning neuroinflammatory cascade in their description or question text
No additional research found