protein

INSULIN-LIKE GROWTH FACTOR 1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSULIN-LIKE GROWTH FACTOR 1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

14Outgoing

16Incoming

0Experiments

0Debates

Summary

Page for Insulin-Like Growth Factor 1 Protein

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🔬 Protein Info

Gene Symbol	INSULIN
Full Name	LIKE GROWTH FACTOR 1
GeneCards	INSULIN
Human Protein Atlas	INSULIN
Known Drugs/Compounds	semaglutide
Interactions	AKT, AMPK, AMYLOID, APP, CLU, EGFR
KG Connections	325 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    INSULIN_LIKE_GROWTH_FACTOR_1["INSULIN-LIKE GROWTH FACTOR 1"]
    inflammation["inflammation"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"regulates"| inflammation
    INSULIN["INSULIN"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"regulates"| INSULIN
    COMPLEMENT["COMPLEMENT"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"activates"| COMPLEMENT
    AMYLOID["AMYLOID"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"activates"| AMYLOID
    AMYLOID_BETA["AMYLOID BETA"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"activates"| AMYLOID_BETA
    Melanoma["Melanoma"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"activates"| Melanoma
    INSULIN["INSULIN"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"activates"| INSULIN
    IGF_1["IGF-1"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"activates"| IGF_1
    PDGF["PDGF"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"activates"| PDGF
    CYTOKINE["CYTOKINE"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"activates"| CYTOKINE
    Tgf__["Tgf-Beta"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"regulates"| Tgf__
    IGF_1["IGF-1"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"regulates"| IGF_1
    RAPAMYCIN["RAPAMYCIN"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"regulates"| RAPAMYCIN
    INSULIN["INSULIN"]
    INSULIN_LIKE_GROWTH_FACTOR_1 -->|"associated with"| INSULIN
    Neuroinflammation["Neuroinflammation"]
    Neuroinflammation -->|"regulates"| INSULIN_LIKE_GROWTH_FACTOR_1
    IGF1R["IGF1R"]
    IGF1R -->|"regulates"| INSULIN_LIKE_GROWTH_FACTOR_1
    INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR["INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR"]
    INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR -->|"regulates"| INSULIN_LIKE_GROWTH_FACTOR_1
    TGM2["TGM2"]
    TGM2 -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
    S100B["S100B"]
    S100B -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
    HMGB1["HMGB1"]
    HMGB1 -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
    GPNMB["GPNMB"]
    GPNMB -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
    PTX3["PTX3"]
    PTX3 -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
    Pi3K["Pi3K"]
    Pi3K -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
    IGF1["IGF1"]
    IGF1 -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
    IGF1R["IGF1R"]
    IGF1R -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
    EGR1["EGR1"]
    EGR1 -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
    INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR["INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR"]
    INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
    mTOR["mTOR"]
    mTOR -->|"regulates"| INSULIN_LIKE_GROWTH_FACTOR_1
    NRF2["NRF2"]
    NRF2 -->|"regulates"| INSULIN_LIKE_GROWTH_FACTOR_1
    MECP2["MECP2"]
    MECP2 -->|"associated with"| INSULIN_LIKE_GROWTH_FACTOR_1

Outgoing (14)

Target	Relation	Type	Str
COMPLEMENT	activates	pathway	0.50
AMYLOID	activates	gene	0.50
AMYLOID BETA	activates	concept	0.50
Melanoma	activates	disease	0.50
INSULIN	activates	concept	0.50
IGF-1	activates	concept	0.50
PDGF	activates	concept	0.50
CYTOKINE	activates	concept	0.50
INSULIN	associated_with	concept	0.50
inflammation	regulates	pathway	0.50
INSULIN	regulates	concept	0.50
Tgf-Β	regulates	pathway	0.50
IGF-1	regulates	concept	0.50
RAPAMYCIN	regulates	concept	0.50

Incoming (16)

Source	Relation	Type	Str
mTOR	regulates	entity	0.50
NRF2	regulates	gene	0.50
TGM2	activates	gene	0.50
S100B	activates	gene	0.50
HMGB1	activates	gene	0.50
GPNMB	activates	protein	0.50
PTX3	activates	protein	0.50
Pi3K	activates	pathway	0.50
IGF1	activates	gene	0.50
IGF1R	activates	gene	0.50
EGR1	activates	protein	0.50
INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR	activates	protein	0.50
Neuroinflammation	regulates	process	0.50
IGF1R	regulates	gene	0.50
INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR	regulates	protein	0.50
MECP2	associated_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INSULIN-LIKE GROWTH FACTOR 1 in their description or question text

No additional research found