gene

TERC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TERC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

1Hypotheses

0Analyses

42Outgoing

18Incoming

0Experiments

0Debates

Summary

TERC is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, contributes to. Associated with ALS, Aging, Als. Connected to 36 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TERC
Full Name	Telomerase RNA Component
Chromosome	3q26.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	~451 nucleotides
Pathways	Telomere Dysfunction
NCBI Gene ID	7012
Ensembl ID	ENSG00000264364
OMIM	602322
GeneCards	TERC
Human Protein Atlas	TERC
Associated Diseases	Als, Inflammation, Ms, Senescence
Interactions	IL-6, IL-8, MICRORNAS
KG Connections	60 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TERC Gene

gene · 1067 words

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Pathway Diagram

graph TD
    TERC["TERC"]
    Senescence{"Senescence"}
    TERC -->|"regulates"| Senescence
    Als{"Als"}
    TERC -->|"associated with"| Als
    Ms{"Ms"}
    TERC -->|"regulates"| Ms
    Inflammation{"Inflammation"}
    TERC -->|"regulates"| Inflammation
    TERC -->|"associated with"| Inflammation
    TERC -->|"associated with"| Senescence
    Aging{"Aging"}
    TERC -->|"contributes to"| Aging
    TERC -->|"associated with"| Ms
    Cancer{"Cancer"}
    TERC -->|"contributes to"| Cancer
    TERC -->|"expressed in"| Als
    TERC -->|"expressed in"| Ms
    Schizophrenia{"Schizophrenia"}
    TERC -->|"expressed in"| Schizophrenia
    TERT["TERT"]
    TERT -->|"associated with"| TERC
    AGING["AGING"]
    AGING -->|"contributes to"| TERC
    CANCER["CANCER"]
    CANCER -->|"contributes to"| TERC
    TERT -->|"expressed in"| TERC
    AGING -->|"regulates"| TERC
    CANCER -->|"regulates"| TERC
    P21["P21"]
    P21 -->|"regulates"| TERC
    style TERC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (42)

Target	Relation	Type	Str
Telomere Dysfunction	causes	mechanism	0.95
Telomere Dysfunction	regulates	mechanism	0.85
Telomere Maintenance	involved_in	process	0.85
Telomere Dysfunction	involved_in	process	0.80
Als	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Aging	regulates	disease	0.65
Senescence	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Aging	contributes_to	disease	0.65
Ms	associated_with	disease	0.65
Cancer	contributes_to	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Senescence	associated_with	disease	0.65
RNA	associated_with	gene	0.60
MICRORNAS	interacts_with	gene	0.60
Epigenetic	contributes_to	pathway	0.60
Immune Response	contributes_to	pathway	0.60
INFLAMMATION	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
P16	regulates	gene	0.60
IL-6	regulates	gene	0.60
TERT	associated_with	gene	0.60
GENES	associated_with	gene	0.60
P21	regulates	gene	0.60
Ras	associated_with	protein	0.60
Monocyte	regulates	cell_type	0.60
Cytokine	regulates	protein	0.60
Tau	regulates	protein	0.60
Endothelial	regulates	cell_type	0.60
Endothelial Cell	expressed_in	cell_type	0.55
Telomere	associated_with	pathway	0.50
CYTOKINES	associated_with	concept	0.50
MONOCYTE	activates	concept	0.50
Telomere	activates	pathway	0.50
CYTOKINES	activates	concept	0.50

Incoming (18)

Source	Relation	Type	Str
TERT	associated_with	gene	0.60
TERT	expressed_in	gene	0.60
AGING	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
P16	regulates	gene	0.60
TERT	encodes	gene	0.60
AGING	regulates	gene	0.60
CANCER	regulates	gene	0.60
P21	regulates	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
IL-6	regulates	gene	0.60
RNA	associated_with	gene	0.60
RNA	encodes	gene	0.60
IL-6	activates	protein	0.50
IL-8	activates	protein	0.50
IL-8	associated_with	protein	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Glycan-Targeting Tau Vesicle Interceptors	0.455	neurodegeneration	Do tau-containing vesicles exhibit uniqu

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TERC in their description or question text

No additional research found