| Gene Symbol | IL |
| Full Name | 8 Protein |
| Function | Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation. |
| Subcellular Localization | </strong></td><td>Secreted</td></tr> |
| GeneCards | IL |
| Human Protein Atlas | IL |
| Monomer | 72-residue polypeptide |
| Dimerization | Forms functional dimers at physiological concentrations |
| Receptor binding sites | N-terminal region critical for receptor engagement |
| Heparin-binding domain | Mediates interaction with extracellular matrix |
| Three disulfide bonds | Stabilize tertiary structure |
| Neutrophils | Primary target, induces respiratory burst |
| T lymphocytes | Recruitment to sites of inflammation |
| Monocytes/macrophages | Promotes phagocytosis |
| [Microglia](/entities/microglia) | Activates surveillance phenotype |
| Associated Diseases | CRC |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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