gene

OTULIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OTULIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

27Outgoing

11Incoming

0Experiments

0Debates

Summary

Gene page for OTULIN — OTU deubiquitinase with linear linkage specificity, regulator of NF-κB and linear ubiquitin chains

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🧬 Gene Info

Gene Symbol	OTULIN
Full Name	OTU Deubiquitinase with Linear Linkage Specificity
Chromosome	5p15.2
Protein Type	Protease
Function	Unlike other OTU family members, OTULIN shows exceptional specificity for linear ubiquitin chains and does not efficiently cleave other ubiquitin linkage types.
Pathways	NF-κB signaling, NF-κB Signaling, NF-κB
Ensembl ID	ENSG00000135547
GeneCards	OTULIN
Human Protein Atlas	OTULIN
Alzheimer's Disease	OTULIN regulates tau expression through linear ubiquitin-dependent mechanisms. Dysregulation of OTULIN may contribute to tau pathology in AD. [@ref]
Parkinson's Disease	Implicated in PD pathogenesis through regulation of protein quality control pathways
Amyotrophic Lateral Sclerosis (ALS)	Rare variants may modify ALS risk through effects on proteostasis
Immunodeficiency	Loss-of-function mutations cause OTULIN-related immunodeficiency and inflammatory disease
Cancer	Altered expression in various cancers, affecting cell proliferation and survival
Associated Diseases	Infection, Inflammation
Interactions	IKBKG, INFLAMMATION, MITOCHONDRIA, NFKB, NF-ΚB, PINK1
KG Connections	38 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OTULIN["OTULIN"]
    Inflammation{"Inflammation"}
    OTULIN -->|"activates"| Inflammation
    Als{"Als"}
    OTULIN -->|"activates"| Als
    Ms{"Ms"}
    OTULIN -->|"activates"| Ms
    NFKB["NFKB"]
    OTULIN -->|"activates"| NFKB
    IKBKG["IKBKG"]
    OTULIN -->|"activates"| IKBKG
    Lysosomal_Degradation(["Lysosomal Degradation"])
    OTULIN -->|"activates"| Lysosomal_Degradation
    Nf__b(["Nf-Kappab"])
    OTULIN -->|"activates"| Nf__b
    neurodegeneration["neurodegeneration"]
    OTULIN -->|"implicated in"| neurodegeneration
    PINK1["PINK1"]
    PINK1 -->|"activates"| OTULIN
    NF__B["NF-KappaB"]
    NF__B -->|"activates"| OTULIN
    TNF["TNF"]
    TNF -->|"activates"| OTULIN
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"activates"| OTULIN
    MITOCHONDRIA["MITOCHONDRIA"]
    MITOCHONDRIA -->|"activates"| OTULIN
    AND["AND"]
    AND -->|"activates"| OTULIN
    style OTULIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
Als	activates	disease	0.75
Inflammation	activates	disease	0.65
Infection	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	activates	disease	0.65
Nf-Κb	activates	pathway	0.60
LYSOSOME	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
Stem Cell	activates	pathway	0.60
IKBKG	activates	gene	0.60
Autophagy	regulates	pathway	0.60
Ferroptosis	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Pyroptosis	regulates	pathway	0.60
PYROPTOSIS	regulates	gene	0.60
NF-ΚB	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
Necroptosis	regulates	pathway	0.60
FERROPTOSIS	regulates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
SHARPIN	associated_with	gene	0.60
CYLD	associated_with	gene	0.60
TNF	activates	gene	0.60
NFKB	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
Lysosomal Degradation	activates	pathway	0.60

Incoming (11)

Source	Relation	Type	Str
NF-ΚB	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
CYLD	associated_with	gene	0.60
PINK1	activates	gene	0.60
TNF	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
NFKB	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
IKBKG	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning OTULIN in their description or question text

No additional research found