gene 2,115 words KG: FANCA
Contents

FANCA Gene

🧬 Gene Info
Gene SymbolFANCA
Full NameFanconi Anemia Group A
Chromosome16q24.3
Molecular Weight180 kDa
Amino Acids1635 aa
Exons43
UniProt ID[O15360](https://www.uniprot.org/uniprot/O15360)
Ensembl IDENSG00000188191
OMIM607139
GeneCardsFANCA
Human Protein AtlasFANCA
Bone marrowHighest expression, consistent with the essential role in hematopoiesis
TestisHigh expression, reflecting ongoing spermatogenesis
Associated DiseasesFanconi Anemia
InteractionsATM, ATR, DNA, FANCC, FANCD2, FANCE
KG Connections33 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
APOE-Dependent Autophagy Restoration
Score: 0.85
PARP1 Inhibition Therapy
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Multi-Modal CRISPR Platform for Simultaneous Editing and Mon
Score: 0.63
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived

See Also (9)

Apoptosis in Neurodegeneration
entity · KG edge: contributes_to
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: interacts_with
ATM Gene
gene · KG edge: interacts_with
ATR Gene
gene · KG edge: interacts_with
fance
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

FANCD2 interacts_with FANCA
FANCA interacts_with TUFM
FANCC interacts_with FANCA
ATM interacts_with FANCA
FANCA interacts_with FANCE
FANCA contributes_to AIM2
FANCA interacts_with ATR
ATR interacts_with FANCA
AIM2 contributes_to FANCA
FANCE interacts_with FANCA

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