entity

LRRK2 mutations

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRRK2 mutations: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections
0Hypotheses
1Analyses
5Outgoing
6Incoming
0Experiments
1Debates

No AI portrait yet

Outgoing (5)

TargetRelationTypeStr
benchmark_ot_ad_answer_key:LRRK2 MUTATIONSdata_indataset_row0.00
Autosomal Dominant Parkinson's Diseasecausesdisease0.90
Parkinson's Diseasecausesdisease0.85
Crohn's diseasecausesdisease0.80
Parkinson's diseasecausesdisease0.80

Incoming (6)

SourceRelationTypeStr
benchmark_ot_ad_answer_key:LRRK2 MUTATIONSdata_indataset_row0.00
40661559increasepaper0.90
23066449are present inpaper0.90
38307024causepaper0.90
36085537linked topaper0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does LRRK2's role as a lysosomal volume sensor explain the pathogenic mechanism

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.666

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While the study establishes LRRK2 as a lysosomal swelling sensor and notes that

closed · Rounds: 4 · Score: 0.85 · 2026-04-16

Related Research

Hypotheses and analyses mentioning LRRK2 mutations in their description or question text

No additional research found