| Gene Symbol | COFILIN |
| Aliases | Actin-Depolymerizing Factor |
| Function | Cofilin-1 is a key regulator of actin cytoskeleton dynamics |
| Molecular Weight | 19 kDa |
| GeneCards | COFILIN |
| Human Protein Atlas | COFILIN |
| Actin-binding interface | Binds to both G-actin (globular) and F-actin (filamentous) forms |
| Phosphoinositide-binding site | Enables membrane localization and regulation by phosphoinositides |
| Nuclear localization signal (NLS) | Allows translocation to the nucleus |
| Phosphorylation site | Ser3 phosphorylation regulates activity |
| Associated Diseases | neurodegeneration |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, EFHD2, INFLAMMATION |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!