protein

ATP1A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP1A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

24Outgoing

6Incoming

0Experiments

0Debates

Summary

ATP1A1 is a protein involved in neurodegeneration research. Key relationships include: associated with, contributes to, regulates. Associated with Aging, Als, Cardiovascular. Connected to 25 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	ATP1A1
Full Name	ATPase Na+/K+ Transporting Subunit Alpha 1
Chromosome	1p13.1
Function	ATP1A1 encodes the alpha-1 subunit of Na+/K+ ATPase.
Primary Expression	most cell types including neurons, astrocytes, and oligodendrocytes
Subcellular Localization	</th><td>Plasma membrane</td></tr>
Molecular Weight	112 kDa
Amino Acids	1000 aa
Pathways	Apoptosis, Immune Response
UniProt ID	[P05023](https://www.uniprot.org/uniprotkb/P05023/entry)
GeneCards	ATP1A1
Human Protein Atlas	ATP1A1
Energy failure	Reduced ATPase activity contributes to neuronal hyperexcitability and vulnerability
Calcium dysregulation	Impaired Na+ gradient affects NCX function, leading to calcium overload
Therapeutic relevance	Cardiac glycosides (digoxin, ouabain) that inhibit Na+/K+ ATPase show complex effects in AD models [2]
Associated Diseases	Aging, Als, Cardiovascular, Ms
KG Connections	29 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATP1A1 Protein

protein · 657 words

→

ATP1A1 Gene

gene · 607 words

→

Pathway Diagram

graph TD
    ATP1A1["ATP1A1"]
    Ms{"Ms"}
    ATP1A1 -->|"regulates"| Ms
    Als{"Als"}
    ATP1A1 -->|"associated with"| Als
    Aging{"Aging"}
    ATP1A1 -->|"associated with"| Aging
    ATP1A1 -->|"associated with"| Ms
    Cardiovascular{"Cardiovascular"}
    ATP1A1 -->|"associated with"| Cardiovascular
    RAB11B["RAB11B"]
    ATP1A1 -->|"regulates"| RAB11B
    AMBRA1["AMBRA1"]
    ATP1A1 -->|"regulates"| AMBRA1
    SORT1["SORT1"]
    ATP1A1 -->|"regulates"| SORT1
    APOPTOSIS["APOPTOSIS"]
    ATP1A1 -->|"regulates"| APOPTOSIS
    Apoptosis(["Apoptosis"])
    ATP1A1 -->|"regulates"| Apoptosis
    Immune_Response(["Immune Response"])
    ATP1A1 -->|"regulates"| Immune_Response
    PRDX6["PRDX6"]
    ATP1A1 -->|"contributes to"| PRDX6
    AGING["AGING"]
    AGING -->|"associated with"| ATP1A1
    TSC1["TSC1"]
    TSC1 -->|"contributes to"| ATP1A1
    CREB3["CREB3"]
    CREB3 -->|"contributes to"| ATP1A1
    style ATP1A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ATP1A1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
neuronal hyperexcitability	inhibits	phenotype	0.85
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ms	regulates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Mapk	contributes_to	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Apoptosis	regulates	pathway	0.60
APOPTOSIS	regulates	gene	0.60
Immune Response	regulates	pathway	0.60
HSPB1	contributes_to	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
Notch	associated_with	pathway	0.60
RAB11B	regulates	gene	0.60
AMBRA1	regulates	gene	0.60
SORT1	regulates	gene	0.60
PRDX6	contributes_to	gene	0.60
YWHAZ	contributes_to	gene	0.60
MAPK14	contributes_to	gene	0.60
LMNA	contributes_to	gene	0.60
RAGE	associated_with	gene	0.60

Incoming (6)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATP1A1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
APOE4	downregulates	gene	0.90
TSC1	contributes_to	gene	0.60
CREB3	contributes_to	gene	0.60
AGING	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATP1A1 in their description or question text

No additional research found