Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about neuronal hyperexcitability: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Inhibitory Synapse Elimination | causes | process | 0.95 |
| KCNQ2 Mis-splicing | causes | mechanism | 0.93 |
| FST | promotes | protein | 0.92 |
| Mitochondrial Dysfunction | causes | process | 0.88 |
| Antisense Oligonucleotides | treats | drug | 0.87 |
| Microglia | associated_with | cell_type | 0.85 |
| Atp1A1 | inhibits | protein | 0.85 |
| AKT | modulates | protein | 0.85 |
| TRPM7 | contributes_to | gene | 0.85 |
| NOTCH2NLC | causes | gene | 0.80 |
| TDP-43 | promotes | protein | 0.70 |
| SDUY-225 | protects_against | drug | 0.70 |
| tau | causes | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Disrupted AQP4-Mediated K+ Spatial Buffering Causes Neuronal | 0.580 | neurodegeneration | What are the specific molecular mechanis |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.640
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning neuronal hyperexcitability in their description or question text
No additional research found