| Gene Symbol | ATP1A1 |
| Full Name | ATPase Na+/K+ Transporting Subunit Alpha 1 |
| Chromosome | 1p13.1 |
| Function | ATP1A1 encodes the alpha-1 subunit of Na+/K+ ATPase. |
| Primary Expression | most cell types including neurons, astrocytes, and oligodendrocytes |
| Subcellular Localization | </th><td>Plasma membrane</td></tr> |
| Molecular Weight | 112 kDa |
| Amino Acids | 1000 aa |
| Pathways | Apoptosis, Immune Response |
| UniProt ID | [P05023](https://www.uniprot.org/uniprotkb/P05023/entry) |
| GeneCards | ATP1A1 |
| Human Protein Atlas | ATP1A1 |
| Energy failure | Reduced ATPase activity contributes to neuronal hyperexcitability and vulnerability |
| Calcium dysregulation | Impaired Na+ gradient affects NCX function, leading to calcium overload |
| Associated Diseases | Aging, Als, Cardiovascular, Ms |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!