gene

amyloid aggregation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about amyloid aggregation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

1Analyses

0Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	AMYLOID
Full Name	amyloid aggregation
Function	is a critical molecular neuroimaging biomarker that visualizes fibrillar amyloid-beta (Aβ) plaque burden in vivo.
GeneCards	AMYLOID
Human Protein Atlas	AMYLOID
Associated Diseases	AQP4, astrocytes, MAPT, PSEN1, APP, APOE
KG Connections	65 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    APP["APP"] -->|"associated"| amyloid_aggregation["amyloid aggregation"]
    style APP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    oxidative_stress_response["oxidative stress response"] -->|"mediates"| amyloid_aggregation["amyloid aggregation"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    microglia["microglia"] -->|"activates"| amyloid_aggregation["amyloid aggregation"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    astrocytes["astrocytes"] -->|"associated"| amyloid_aggregation["amyloid aggregation"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TREM2["TREM2"] -->|"regulates"| amyloid_aggregation["amyloid aggregation"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style amyloid_aggregation fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (66)

Source	Relation	Type	Str
TDP-43 CTD	promotes	protein	0.92
oxidative stress response	mediates	pathway	0.80
APP	associated_with	gene	0.80
microglia	activates	cell_type	0.80
BACE1	regulates	gene	0.70
TREM2	regulates	gene	0.70
microglia	regulates	cell_type	0.70
astrocytes	regulates	cell_type	0.70
astrocytes	associated_with	cell_type	0.70
microglia	inhibits	cell_type	0.70
TREM2	interacts_with	gene	0.70
microglia	interacts_with	cell_type	0.70
IL-1β signaling	accelerates	pathway	0.70
PI3K	regulates	gene	0.60
PI3K-AKT-mTOR signaling	mediates	pathway	0.60
ISG	activates	gene	0.60
SREBP2	activates	gene	0.60
BACE1	activates	gene	0.60
CYP46A1	activates	gene	0.60
ABCA1	activates	gene	0.60
GSK3B	activates	gene	0.60
TREM2	activates	gene	0.60
Wnt signaling	mediates	pathway	0.60
GFAP	associated_with	gene	0.60
IBA1	associated_with	gene	0.60
microglia	associated_with	cell_type	0.60
DNAJB6	inhibits	gene	0.60
DNAJB6	interacts_with	gene	0.60
APOE3	associated_with	gene	0.60
C1QB	interacts_with	gene	0.60
SIRT2	protects_against	gene	0.60
APP	protects_against	gene	0.60
microglia	protects_against	cell_type	0.60
BIN1	associated_with	gene	0.60
BIN1	interacts_with	gene	0.60
oligodendrocytes	interacts_with	cell_type	0.60
NGF	associated_with	gene	0.60
INPP5D	activates	gene	0.60
LGALS3	regulates	gene	0.60
APOE4	regulates	gene	0.60
PLCG2	interacts_with	gene	0.60
FUS	activates	gene	0.60
astrocytes	activates	cell_type	0.60
CREB	activates	gene	0.60
TNF	activates	gene	0.60
BDNF	activates	gene	0.60
RNA	activates	gene	0.60
TREM2	protects_against	gene	0.60
macrophages	protects_against	cell_type	0.60
ADAM10	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does APOE4's beneficial immune function reconcile with its established role

neurodegeneration | 2026-04-12 | 1 hypotheses Top: 0.575

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does APOE4's beneficial immune function reconcile with its established role

closed · Rounds: 4 · Score: 0.78 · 2026-04-12

Related Research

Hypotheses and analyses mentioning amyloid aggregation in their description or question text

No additional research found