protein

PTX3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

17Outgoing

13Incoming

0Experiments

0Debates

Summary

Key innate immune protein with roles in neuroinflammation, complement activation, and biomarker potential in neurodegenerative diseases

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	PTX3
Chromosome	3q28
Function	The protein is encoded by the PTX3 gene located on chromosome 3q28 and consists of 381 amino acids.
Amino Acids	381 aa
Pathways	COMPLEMENT
GeneCards	PTX3
Human Protein Atlas	PTX3
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Interactions	ADIPOQ, AMYLOID, APP, C1Q, C3, FH
KG Connections	30 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

PTX3 Protein (Pentraxin 3)

protein · 2066 words

→

Pathway Diagram

graph TD
    PTX3("PTX3")
    INSULIN_LIKE_GROWTH_FACTOR_1("INSULIN-LIKE GROWTH FACTOR 1")
    PTX3 -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
    COMPLEMENT(["COMPLEMENT"])
    PTX3 -->|"activates"| COMPLEMENT
    AMYLOID["AMYLOID"]
    PTX3 -->|"activates"| AMYLOID
    AMYLOID_BETA["AMYLOID BETA"]
    PTX3 -->|"activates"| AMYLOID_BETA
    Melanoma{"Melanoma"}
    PTX3 -->|"activates"| Melanoma
    INSULIN["INSULIN"]
    PTX3 -->|"activates"| INSULIN
    IGF_1["IGF-1"]
    PTX3 -->|"activates"| IGF_1
    PRMT1["PRMT1"]
    PTX3 -->|"regulates"| PRMT1
    Glioma{"Glioma"}
    PTX3 -->|"regulates"| Glioma
    TGM2["TGM2"]
    TGM2 -->|"activates"| PTX3
    S100B["S100B"]
    S100B -->|"activates"| PTX3
    HMGB1["HMGB1"]
    HMGB1 -->|"activates"| PTX3
    GPNMB("GPNMB")
    GPNMB -->|"activates"| PTX3

Outgoing (17)

Target	Relation	Type	Str
complement cascade	participates_in	pathway	0.60
S100B	activates	gene	0.60
TGM2	activates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.55
macrophages	expressed_in	cell_type	0.55
Melanoma	activates	disease	0.50
INSULIN-LIKE GROWTH FACTOR 1	activates	protein	0.50
IGF-1	activates	concept	0.50
INSULIN	activates	concept	0.50
COMPLEMENT	activates	pathway	0.50
AMYLOID	activates	gene	0.50
AMYLOID BETA	activates	concept	0.50
PRMT1	regulates	concept	0.50
Glioma	regulates	disease	0.50

Incoming (13)

Source	Relation	Type	Str
ADIPOQ	activates	gene	0.60
APP	activates	gene	0.60
C1Q	activates	gene	0.60
C3	activates	gene	0.60
GHRL	activates	gene	0.60
LDH	activates	gene	0.60
NLRP3	activates	gene	0.60
FH	activates	gene	0.60
C3	interacts_with	gene	0.55
TGM2	activates	gene	0.50
S100B	activates	gene	0.50
HMGB1	activates	gene	0.50
GPNMB	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PTX3 in their description or question text

No additional research found