| Gene Symbol | PTX3 |
| Aliases | PTX3PROTEIN |
| Chromosome | 3q28 |
| Function | The protein is encoded by the PTX3 gene located on chromosome 3q28 and consists of 381 amino acids. |
| Amino Acids | 381 aa |
| Pathways | COMPLEMENT |
| GeneCards | PTX3 |
| Human Protein Atlas | PTX3 |
| Multiple glycosylation sites | N-linked glycosylation at Asn positions affecting protein function |
| TNF-α responsive region | Induced by pro-inflammatory cytokines |
| Pentraxin signature motif | H[FL]X3SYX2[AS]X[ST] (amino acids 317-327) |
| Calcium-binding sites | Essential for ligand recognition |
| Quaternary structure | Forms an octameric complex via disulfide bonds |
| Pathogens | Fungal (Aspergillus, Candida), bacterial (Pseudomonas, Klebsiella) |
| Apoptotic cells | Phosphatidylserine exposure |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Interactions | ADIPOQ, AMYLOID, APP, C1Q, C3, FH |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!