| Gene Symbol | TFEB |
| Aliases | Transcription Factor EB |
| Protein Type | Transcription Factor |
| Target Class | Protein |
| Function | TFEB is constitutively expressed in most cell types, with highest expression in tissues with high lysosomal activity including: |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction |
| Primary Expression | most cell types, with highest expression in tissues with high lysosomal activity including: |
| Druggability | Undruggable (0.23) |
| Molecular Weight | 53 kDa |
| Pathways | mTOR |
| GeneCards | TFEB |
| Human Protein Atlas | TFEB |
| Associated Diseases | aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | bortezomib, curcumin, CURCUMIN, digoxin, ELTROMBOPAG, hederagenin |
| Interactions | ABCA1, ACAT1, ACETYL-COA, ACHE, ACOD1, ACOX1 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Cell-Type Specific TFEB Modulation The Mitochondrial-Lysosomal Metabolic Coupling Dys Radiation drives pericyte senescence through lysos (+4 more) |
| KG Connections | 3007 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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