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TFEB

TFEB Protein

Score: 0.337 Price: $0.34 Undruggable Druggability Status: active Wiki: TFEB
HYPOTHESES
1
PAPERS
12
KG EDGES
3
DEBATES
0

3D Protein Structure

🧬 TFEB — PDB 5HQB Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability
Undruggable
Score: 0.23
Clinical Stage
Preclinical
Target Class
Protein
Safety
0.50
Druggability Analysis
Drug Development0.00
Structural Tractability0.30
Target Class0.50
Safety Profile0.50
Key Metrics
PDB Structures:
0
Known Drugs:
0
Approved:
0
In Clinical Trials:
0
Mechanism: Prioritized from 1 SciDEX hypotheses, including: The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Known Drugs:
No known drugs targeting this protein
Structural Data:
PDB —AlphaFold ✓Cryo-EM —
UniProt: O14964

🧬 3D Protein Structure

🧬 TFEB — PDB 5HQB Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

Open full viewer

AlphaFold predicted structure available for O14964

View AlphaFold Structure

Linked Hypotheses (6)

Cell-Type Specific TFEB Modulation0.677
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction0.652
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling0.622
Temporal TFEB Modulation Therapy0.609
TFEB Activation Clears Tau-Loaded Endolysosomal Compartments, Preventing Release for Transcellular S0.560
TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inflammasome Regulation0.485

Linked Experiments (6)

Trehalose-induced lysosomal membrane permeabilization and TFEB activation0.900
Trehalose-induced lysosomal changes and TFEB activation0.900
Transcriptome sequencing of cardiac fibroblasts in TFEB overexpressing mice0.900
TFEB silencing and misfolded protein degradation0.880
Functional validation of trehalose effects on misfolded protein clearance0.850
Trehalose analog testing for autophagy induction0.820

Scoring Dimensions

Portfolio 0.00 (25%) Druggability 0.23 (20%) Evidence 0.84 (20%) Safety 0.50 (15%) Competitive 0.50 (10%) Connectivity 0.00 (10%) 0.337 composite

Knowledge Graph (20)

activates (8)

trehalose→TFEBhederagenin→TFEBTFEB→Autophagy-lysosomal pathwayElectroacupuncture→TFEBTFEB→BECN1
▸ Show 3 more
TRIM27→TFEBTFEB→autophagyCREB1→TFEB

associated with (1)

TFEB→endocytosis

inhibits (2)

IL6→TFEBAKT-MAPK1-MTORC1 pathway→TFEB

regulates (9)

TFEB→RRAGDTFEB→PPARGC1ATFEB→autophagyPPARA→TFEBTFEB→lysosomal biogenesis
▸ Show 4 more
TFEB→autophagy-lysosomal pathwayTFEB→LC3TFEB→RRAGTFEB→macroautophagy/autophagy-lysosomal pathway

Debate History (0)

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