protein 748 words KG: PEN2
Contents

Presenilin Enhancer 2 (PEN-2) Protein

🔬 Protein Info
Gene SymbolPSENEN
AliasesPresenilin Enhancer 2
Chromosome19q13.12
Protein FamilyPEN-2 family (γ-secretase complex)
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionEndoplasmic reticulum, Golgi apparatus, plasma membrane
Molecular Weight12 kDa
Amino Acids101 aa
PathwaysAngiogenesis
UniProt IDQ9NQ75
GeneCardsPSENEN
Human Protein AtlasPSENEN
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI
InteractionsA2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APH1B
KG Connections96 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (11)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (13)

Apoptosis in Neurodegeneration
entity · KG edge: interacts_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: interacts_with
A2M Gene
gene · KG edge: interacts_with
ANG — Angiogenin
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NCSTN interacts_with PEN2
FAS interacts_with PEN2
TNF interacts_with PEN2
LMNA interacts_with PEN2
APH1B interacts_with PEN2
APOE interacts_with PEN2
IL6 interacts_with PEN2
SREBF1 interacts_with PEN2
PSEN2 interacts_with PEN2
A2M interacts_with PEN2

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