| Gene Symbol | NOS1 |
| Aliases | Nitric Oxide Synthase 1 |
| Chromosome | 12q24.2 |
| Protein Type | Enzyme |
| Function | NOS1 produces nitric oxide, which serves multiple functions in the nervous system. |
| Subcellular Localization | Cytoplasm, Membrane |
| Molecular Weight | 160 kDa |
| Pathways | MAPK signaling, lipid metabolism, oxidative stress response |
| UniProt ID | P70689 (mouse), Q9WU75 (rat) |
| Ensembl ID | ENSG00000089250 |
| GeneCards | NOS1 |
| Human Protein Atlas | NOS1 |
| N-terminal PDZ domain | Localizes to synaptic membranes |
| Oxygenase domain | Contains heme and substrate binding sites |
| Calmodulin-binding domain | Calcium-dependent activation |
| Associated Diseases | Als, neuroinflammation, oxidative stress |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, APOE, ASTROCYTE, ASTROCYTES |
| KG Connections | 72 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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