gene 2,170 words KG: HIP1R
Contents

HIP1R (Huntingtin Interacting Protein 1-Related)

🧬 Gene Info
Gene SymbolHIP1R
AliasesSLAIN2, B murine sarcoma virus CT10
Chromosome22q13.31
Protein TypeClathrin coat component, Actin-binding protein
Functionencodes a critical protein involved in clathrin-mediated endocytosis, actin cytoskeleton organization, and cellular trafficking.
Primary Expressionthe brain, particularly in neurons of the cortex, hippocampus, and cerebellum, where it performs essential roles in synaptic vesicle trafficking, rece
Molecular Weight116 kDa
Amino Acids1031 aa
Ensembl IDENSG00000128284
GeneCardsHIP1R
Human Protein AtlasHIP1R
Associated DiseasesAls
KG Connections11 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

Cardiac MIBG Scan for Parkinsonism
diagnostic · KG edge: regulates
Neurodegeneration
disease · KG edge: implicated_in
SCN1A
gene · KG edge: regulates
CFTR Gene
gene · KG edge: regulates
EPHB4 Gene
gene · KG edge: associated_with

Knowledge Graph (11 edges)

RYR2 regulates HIP1R
SCN1A regulates HIP1R
ROBO1 associated_with HIP1R
GAD2 regulates HIP1R
PIK3CB regulates HIP1R
NOS1 regulates HIP1R
CFTR regulates HIP1R
EPHB4 associated_with HIP1R
MMP2 associated_with HIP1R
HIP1R associated_with Als

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