| Gene Symbol | RYR2 |
| Aliases | Page for RYR2 |
| Protein Family | Ryanodine receptor family |
| Protein Type | Channel |
| Function | RYR2 is the cardiac ryanodine receptor, essential for calcium-induced calcium release in heart muscle. |
| Primary Expression | various neuronal populations including hippocampal neurons and cerebellar granule cells, where it contributes to synaptic plastic |
| Molecular Weight | 565 kDa |
| Amino Acids | 647 aa |
| Exons | 105 |
| Pathways | Apoptosis, Nf-Κb, Oxidative Phosphorylation |
| UniProt ID | Q92736 |
| GeneCards | RYR2 |
| Human Protein Atlas | RYR2 |
| FKBP12.6 (calstabin-2) | Stabilizes the closed state of RYR2 |
| Phosphorylation | PKA phosphorylation at Ser2808 enhances channel open probability |
| Associated Diseases | Aging, Als, cancer, Cardiac |
| Interactions | AND, APOPTOSIS, ASTROCYTE, ASTROCYTES, BRAIN INJURY, DRP1 |
| KG Connections | 95 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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