| Gene Symbol | NOS1 |
| Full Name | Nitric Oxide Synthase 1 |
| Chromosome | 12q24.2 |
| Protein Type | Enzyme |
| Function | NOS1 produces nitric oxide, which serves multiple functions in the nervous system. |
| Subcellular Localization | Cytoplasm, Membrane |
| Molecular Weight | 160 kDa |
| Pathways | MAPK signaling, lipid metabolism, oxidative stress response |
| UniProt ID | P70689 (mouse), Q9WU75 (rat) |
| Ensembl ID | ENSG00000089250 |
| GeneCards | NOS1 |
| Human Protein Atlas | NOS1 |
| Presynaptic plasticity | NO regulates the release of various neurotransmitters including glutamate, GABA, dopamine, and acetylcholine |
| Retrograde signaling | NO acts as a messenger for long-term potentiation (LTP) and long-term depression (LTD) |
| Neuromodulation | NO influences neuronal excitability and firing patterns |
| Associated Diseases | Als, neuroinflammation, oxidative stress |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, APOE, ASTROCYTE, ASTROCYTES |
| KG Connections | 73 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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