protein 605 words KG: MFN1
Contents

Mitofusin 1 (MFN1)

🔬 Protein Info
Gene SymbolMFN1
Chromosome3q26.33
FunctionMitofusin 1 (MFN1) is a dynamin-like GTPase essential for mitochondrial outer membrane fusion
Primary Expressionhippocampus, Cerebellum, Cortex, Striatum, Substantia Nigra
Molecular Weight83 kDa
PathwaysApoptosis, Autophagy, Epigenetic, Lysosomal Degradation, Mitochondrial Function
GeneCardsMFN1
Human Protein AtlasMFN1
Associated DiseasesAD, ALI, Als, Alzheimer, COPD
InteractionsABCD3, Actin, AGING, AKT, ALS, ALZHEIMER
KG Connections921 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

Related Hypotheses (22)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.97
Transcriptional Autophagy-Lysosome Coupling
Score: 0.92
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
pg 1/2Next →

Related Analyses (7)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (6)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: activates
AMBRA1 Gene
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (12 edges)

CAT interacts_with MFN1
OPTN interacts_with MFN1
DNM1L interacts_with MFN1
CANX interacts_with MFN1
LGALS3 interacts_with MFN1
CALCOCO2 interacts_with MFN1
G3BP1 interacts_with MFN1
PEX3 interacts_with MFN1
SQSTM1 interacts_with MFN1
BCL2 interacts_with MFN1

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)