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protein 1,013 words KG: BCL2
Contents

BCL2 (B-Cell Lymphoma 2)

🔬 Protein Info
Gene SymbolBCL2
AliasesB-cell lymphoma 2
Protein FamilyBCL-2 family (anti-apoptotic subfamily)
FunctionDirect BAX/BAK inhibition
Subcellular Localization** Mitochondrial outer membrane, ER, nuclear envelope
Molecular Weight26 kDa
PathwaysAkt, Apoptosis, Autophagy, BMP signaling, Bh4 Domain
UniProt IDP10415
GeneCardsBCL2
Human Protein AtlasBCL2
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsAbt263, ABT263, ABT-737, Adcs, berberine, BERBERINE
InteractionsABCD3, ABP, ACETYL-COA, ACHE, Actin, AD
KG Connections2849 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (54)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72Autophagosome Maturation Checkpoint Control
Score: 0.71TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71Lysosomal Calcium Channel Modulation Therapy
Score: 0.70Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Extracellular Matrix Stiffness Modulation
Score: 0.69Cross-Seeding Prevention Strategy
Score: 0.69Lysosomal Positioning Dynamics Modulation
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67RNA Granule Nucleation Site Modulation
Score: 0.66Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
← Prevpg 2/3Next →

Related Analyses (16)

Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (5)

ABCA7 (Redirect)
redirect · KG edge: associated_withABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_targetABCD3 Gene
gene · KG edge: activatesADORA2A Gene
gene · KG edge: interacts_withAging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: degrades

Knowledge Graph (12 edges)

BMAL1 regulates BCL2
BCL2 interacts_with IP3R
BCL2 regulates MITOCHONDRIAL_CA
STAT3 regulates BCL2
BCL2 treats Ph_like_ALL
CAT interacts_with BCL2
OPTN interacts_with BCL2
DNM1L interacts_with BCL2
CANX interacts_with BCL2
LGALS3 interacts_with BCL2

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