Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about OPC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | OPC |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
OPC["OPC"]
OPC -->|"expressed in"| White_Matter["White Matter"]
OPC -->|"expressed in"| Cortex["Cortex"]
OPC -->|"expressed in"| Hippocampus["Hippocampus"]
RNA["RNA"] -->|"regulates"| OPC
GPR37["GPR37"] -->|"regulates"| OPC
MYELIN["MYELIN"] -->|"regulates"| OPC
DEMENTIA["DEMENTIA"] -->|"interacts"| OPC
SERPINE2["SERPINE2"] -->|"activates"| OPC
TAUOPATHY["TAUOPATHY"] -->|"activates"| OPC
ASTROCYTE["ASTROCYTE"] -->|"activates"| OPC| Target | Relation | Type | Str |
|---|---|---|---|
| oligodendrocyte | associated_with | cell_type | 0.75 |
| White Matter | expressed_in | brain_region | 0.50 |
| Cortex | expressed_in | brain_region | 0.50 |
| Hippocampus | expressed_in | brain_region | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GPR37 | regulates | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| CD44 | expressed_in | gene | 0.60 |
| GBM | associated_with | gene | 0.60 |
| KCND2 | associated_with | gene | 0.60 |
| MTOR | expressed_in | gene | 0.60 |
| SLC12A5 | causes | gene | 0.60 |
| FLOT1 | causes | gene | 0.60 |
| STROKE | contributes_to | gene | 0.60 |
| ASTROCYTES | contributes_to | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| MYELIN | regulates | gene | 0.60 |
| ASTROCYTES | inhibits | gene | 0.60 |
| COP1 | causes | gene | 0.60 |
| MICROGLIA | inhibits | gene | 0.60 |
| EPILEPSY | associated_with | gene | 0.60 |
| GLIOBLASTOMA | activates | gene | 0.60 |
| RNA | interacts_with | gene | 0.60 |
| DEMENTIA | interacts_with | gene | 0.60 |
| SERPINE2 | activates | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| MYELIN | associated_with | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| TAUOPATHY | activates | gene | 0.60 |
| Als | activates | disease | 0.55 |
| Vascular Dementia | interacts_with | disease | 0.55 |
| Ischemia | interacts_with | disease | 0.55 |
| Neurodegeneration | activates | disease | 0.55 |
| Als | regulates | disease | 0.55 |
| Als | expressed_in | disease | 0.55 |
| Cancer | associated_with | disease | 0.55 |
| Traumatic Brain Injury | expressed_in | disease | 0.55 |
| Ischemia | expressed_in | disease | 0.55 |
| Als | inhibits | disease | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| OPC differentiation blockade contributes to white matter deg | 0.599 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
| ELF2-Mediated OPC Epigenetic Drift Drives Region-Dependent M | 0.508 | Alzheimer disease | Allen Mouse Brain Aging Atlas: cross-age |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.869
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Anti-ASC antibody intracerebroventricular injection in APP/PS1 mice | validation | Alzheimer's disease | 0.950 | 0.00 | APP/PS1 transgenic mice (8 mon | proposed | N/A |
| PDGFRA and C-MYC protein validation in ovarian cancer tissues | exploratory | Ovarian cancer | 0.850 | 0.00 | Human ovarian cancer tissues | proposed | N/A |
| CD2AP expression and cognitive decline in AD patients | exploratory | Alzheimer's disease | 0.800 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal St [PMID:41270149] | Li C, Teng T, Lin X, Sun X, Yi T et al. | Cancer Res | 2026 | 0 |
| A cellular epigenetic classification system for glioblastoma. [PMID:41499453] | Silverbush D, Jürgensen L, Freeburg NF, | Neuro Oncol | 2026 | 0 |
| Gastrointestinal Stromal Tumors: Molecular Mechanisms of Drug Resistance and Adv [PMID:41724491] | Jingnuo D, Huachuan Z, Da Z, Zhi D, Yan | J Gastroenterol Hepatol | 2026 | 0 |
| P16(+) Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated [PMID:41766526] | Yan L, Zheng J, Lu Z, Zhu A, Ye M et al. | Circulation | 2026 | 0 |
| Multi-omics reveals heterogeneity and functional populations of oligodendrocyte [PMID:41771834] | Ye D, Zhou H, Qu S, Wang Z, Zhang F et a | Cell Death Discov | 2026 | 0 |
| Prevalent mesenchymal drift in aging and disease is reversed by partial reprogra [PMID:40816266] | Lu JY, Tu WB, Li R | Cell | 2025 | 0 |
| The neuropathobiology of multiple sclerosis. [PMID:38789516] | Woo MS, Engler JB, Friese MA | Nat Rev Neurosci | 2024 | 0 |
| Innate immune memory after brain injury drives inflammatory cardiac dysfunction. [PMID:39043180] | Simats A, Zhang S, Messerer D | Cell | 2024 | 0 |
| The neuropathobiology of multiple sclerosis. [PMID:38789516] | Woo MS, Engler JB, Friese MA | Nature reviews. Neuroscience | 2024 | 0 |
| Innate immune memory after brain injury drives inflammatory cardiac dysfunction. [PMID:39043180] | Simats A, Zhang S, Messerer D, Chong F, | Cell | 2024 | 0 |
| Epigenomic dissection of Alzheimer's disease pinpoints causal variants and revea [PMID:37774680] | Unknown | Cell | 2023 | 0 |
| Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. [PMID:37258678] | Depp C, Sun T, Sasmita AO | Nature | 2023 | 0 |
| Epigenomic dissection of Alzheimer's disease pinpoints causal variants and revea [PMID:37774680] | Xiong, James, Boix, Park, Galani et al. | Cell | 2023 | 0 |
| Oligodendrocyte progenitor cells in Alzheimer's disease: from physiology to path [PMID:37964328] | Zou P, Wu C, Liu TC, Duan R, Yang L | Translational neurodegeneratio | 2023 | 0 |
| Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. [PMID:37258678] | Depp C, Sun T, Sasmita AO, Spieth L, Ber | Nature | 2023 | 0 |
| Oligodendrocyte progenitor cells in Alzheimer's disease: from physiology to path [PMID:37964328] | Zou P, Wu C, Liu TC, Duan R, Yang L | Translational neurodegeneratio | 2023 | 0 |
| Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell [PMID:30936558] | Unknown | Nature neuroscience | 2019 | 0 |
| Oligodendrocytes in Development, Myelin Generation and Beyond. [PMID:31726662] | ["Kuhn Sarah", "Gritti Laura", "Crooks D | Cells | 2019 | 0 |
| Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell [PMID:30936558] | Unknown | Nature neuroscience | 2019 | 0 |
| Oligodendrocytes in Development, Myelin Generation and Beyond. [PMID:31726662] | ["Kuhn Sarah", "Gritti Laura", "Crooks D | Cells | 2019 | 0 |
Multi-agent debates referencing this entity
active · Rounds: 4 · Score: 0.52 · 2026-04-27
active · Rounds: 4 · Score: 0.72 · 2026-04-27
closed · Rounds: 4 · Score: 0.90 · 2026-04-03
Hypotheses and analyses mentioning OPC in their description or question text
No additional research found