concept

SERPINE2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SERPINE2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

18Outgoing

4Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SERPINE2
Key Genes/Proteins	App, CD39, DEMENTIA, LRP1, OLIGODENDROCYTE, RNA
Related Diseases	Als, ALS, Dementia, Ischemia

Pathway Diagram

graph TD
    SERPINE2["SERPINE2"]
    SERPINE2 -->|"interacts"| LRP1["LRP1"]
    SERPINE2 -->|"regulates"| Oligodendrocyte_Progenitor_Cel["Oligodendrocyte Progenitor Cell Differentiation"]
    SERPINE2 -->|"interacts"| Ischemia["Ischemia"]
    SERPINE2 -->|"interacts"| Dementia["Dementia"]
    SERPINE2 -->|"activates"| ALS["ALS"]
    SERPINE2 -->|"interacts"| Vascular_Dementia["Vascular Dementia"]
    SERPINE2 -->|"activates"| Als["Als"]
    SERPINE2 -->|"interacts"| RNA["RNA"]
    DEMENTIA["DEMENTIA"] -->|"interacts"| SERPINE2
    OLIGODENDROCYTE["OLIGODENDROCYTE"] -->|"activates"| SERPINE2
    RNA -->|"interacts"| SERPINE2

Outgoing (18)

Target	Relation	Type	Str
senescent cells	expressed_in	cell_type	0.90
Oligodendrocyte Progenitor Cell Differentiation	regulates	process	0.85
Ischemia	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	activates	disease	0.65
Vascular Dementia	interacts_with	disease	0.65
Als	activates	disease	0.65
Opc	activates	cell_type	0.60
App	interacts_with	protein	0.60
DEMENTIA	interacts_with	gene	0.60
Oligodendrocyte	activates	cell_type	0.60
OLIGODENDROCYTE	activates	gene	0.60
LRP1	associated_with	gene	0.60
RNA	interacts_with	gene	0.60
CD39	associated_with	gene	0.60
White Matter	expressed_in	brain_region	0.55
Progenitor Cell	expressed_in	cell_type	0.55
Oligodendrocyte	expressed_in	cell_type	0.55

Incoming (4)

Source	Relation	Type	Str
DEMENTIA	interacts_with	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
LRP1	associated_with	gene	0.60
RNA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SERPINE2 in their description or question text

No additional research found