Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MEF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MEF2 |
| Key Genes/Proteins | AKT, HDAC, HDAC4, HDAC7, MEF2C, PI3K |
| Related Pathways | epigenetic regulation, oxidative stress response, PI3K/Akt, PI3K/AKT, PI3K-AKT-mTOR signaling |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
MEF2[MEF2]
MEF2 -.biomarker for.-> Soft_Tissue_Sarcoma[Soft Tissue Sarcoma]
MEF2 -->|targets| PI3K[PI3K]
MEF2 -->|inhibits| PTEN[PTEN]
MEF2 -->|activates| MEF2C[MEF2C]
MEF2 -->|participates in| epigenetic_regulation[epigenetic regulation]
MEF2 -->|participates in| PI3K_AKT_mTOR_signaling[PI3K-AKT-mTOR signaling]
MEF2 -->|participates in| ubiquitin_proteasome[ubiquitin-proteasome]
MEF2 -->|participates in| oxidative_stress_response[oxidative stress response]
MEF2 -->|data_in| benchmark_ot_ad_answer_key_MEF[benchmark_ot_ad_answer_key:MEF2]
HDAC4[HDAC4] -->|interacts| MEF2
HDAC7[HDAC7] -->|interacts| MEF2
AKT[AKT] -->|modulates| MEF2
PI3K -->|modulates| MEF2
PI3K_AKT_Pathway[PI3K/AKT Pathway] -->|modulates| MEF2
PI3K_AKT[PI3K/AKT] -->|regulates| MEF2
PI3K_Akt[PI3K/Akt] -->|regulates| MEF2
PTEN -->|regulates| MEF2| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:MEF2 | data_in | dataset_row | 0.00 |
| Soft Tissue Sarcoma | biomarker_for | disease | 0.80 |
| PTEN | inhibits | gene | 0.60 |
| PI3K | inhibits | gene | 0.60 |
| MEF2C | activates | gene | 0.60 |
| epigenetic regulation | participates_in | pathway | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| PI3K | targets | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:MEF2 | data_in | dataset_row | 0.00 |
| HDAC4 | interacts_with | protein | 0.95 |
| HDAC7 | interacts_with | protein | 0.90 |
| 19109909 | regulates | paper | 0.90 |
| AKT | modulates | protein | 0.85 |
| PI3K | modulates | gene | 0.85 |
| PI3K/AKT Pathway | modulates | pathway | 0.85 |
| AKT | phosphorylates | gene | 0.80 |
| PI3K/AKT | regulates | pathway | 0.80 |
| PI3K/Akt | regulates | pathway | 0.70 |
| PTEN | regulates | gene | 0.70 |
| HDAC4 | targets | gene | 0.60 |
| HDAC4 | inhibits | gene | 0.60 |
| HDAC | associated_with | gene | 0.60 |
| HDAC | targets | gene | 0.60 |
| HDAC | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| MEF2C-Dependent Synaptic Gene Regulation | 0.740 | neurodegeneration | What molecular mechanisms mediate HDAC9' |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Activity-dependent PGC-1α transcriptional program analysis | exploratory | neurodevelopmental disorders | 0.800 | 0.00 | mouse cortical neurons | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Renin inhibition improved muscular function by alleviating insulin resistance an [PMID:41391695] | Zhang QY, Ding F, Qin XH, Guo YX, Liu Q | Biochem Pharmacol | 2026 | 0 |
| Regulon Reconstruction Uncovers Novel Deregulated Factors in Alzheimer's Disease [PMID:41729360] | Belém-Souza MV, Barra-Matos G, de Araújo | Mol Neurobiol | 2026 | 0 |
| Single-cell epigenetic landscape, microenvironment interactions, and gene regula [PMID:41844162] | Zhang Z, Cheng WS, Taniguchi-Ponciano K, | Cell Syst | 2026 | 0 |
| Biomimetic KeMA hydrogel encapsulating CAP-EVs-MEF2C for inhibiting inflammation [PMID:41998644] | Guan JB, Lin KY, Wang SX, Wang YG, Li LJ | J Nanobiotechnology | 2026 | 0 |
| PHF2 regulates grip strength via demethylation at the promoter region of the Mef [PMID:42006298] | Fukushima T, Fujioka T, Imai Y, Masubuch | iScience | 2026 | 0 |
| Emerging therapeutic significance of MEF2C: Structure, function and its implicat [PMID:42012028] | Zhang J, Xie Y, Jiang S, Huang S, Lv H e | Dev Dyn | 2026 | 0 |
| Regulon Reconstruction Uncovers Novel Deregulated Factors in Alzheimer's Disease [PMID:41729360] | Belém-Souza MV, Barra-Matos G, de Araújo | Molecular neurobiology | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MEF2 in their description or question text
No additional research found