gene 1,437 words KG: MEF2D
Contents

MEF2D — Myocyte Enhancer Factor 2D

🧬 Gene Info
Gene SymbolMEF2D
Full NameMyocyte Enhancer Factor 2D
AliasesPage for MEF2D Protein
Chromosome5q14.1
Protein TypeTranscription Factor
FunctionNeurotransmitter-related genes
Primary ExpressionCortex, Hippocampus, Striatum, Cerebellum, Substantia Nigra
Molecular Weight55.4 kDa
Amino Acids507 aa
Exons13
PathwaysMAPK
UniProt IDQ01484
NCBI Gene ID4209
Ensembl IDENSG00000105509
OMIM600663
GeneCardsMEF2D
Human Protein AtlasMEF2D
Associated DiseasesParkinson's Disease, Huntington's Disease, Alzheimer's Disease
InteractionsAPOPTOSIS, EP300, MMP9
KG Connections19 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (7)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (9)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: activates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: associated_with
EP300 Gene
gene · KG edge: activates
HDAC7 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

MEF2D associated_with HDAC9
MEF2D regulates HDAC7
MEF2D inhibits MMP9
EP300 activates MEF2D
MMP9 inhibits MEF2D
LRP1 associated_with MEF2D
MEF2D associated_with STAT6
MEF2D activates APOPTOSIS
MEF2D therapeutic_target Aging
MEF2D therapeutic_target Cardiovascular

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