| Gene Symbol | MEF2B |
| Full Name | MEF2B (Myocyte Enhancer Factor 2B) |
| Aliases | Myocyte Enhancer Factor 2B |
| Chromosome | 19p13.11 |
| Protein Type | Gene |
| Function | encodes a transcription factor belonging to the MADS (MEF2, Agamous, Deficiens, serum response factor) box family of DNA-binding proteins. |
| Primary Expression | multiple tissues including adrenal, heart, intestine, kidney, lung, and stomach, reflecting its role in developmental transcriptional programs |
| Amino Acids | 365 aa |
| GeneCards | MEF2B |
| Human Protein Atlas | MEF2B |
| Dimerization | MEF2 proteins form homodimers and heterodimers with other MEF2 family members, expanding their combinatorial diversity |
| DNA binding | The MADS domain directly contacts the major groove of DNA at MEF2 response elements |
| Cofactor recruitment | The domain interacts with various transcriptional coactivators and corepressors, including HDACs |
| Highest expression | Lymphoid tissues including lymph node (RPKM 18.6) and appendix (RPKM 7.2) |
| Moderate expression | Adrenal gland, small intestine, lung, stomach, kidney, and heart |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!