gene 898 words KG: MEF2A
Contents

MEF2A

🧬 Gene Info
Gene SymbolMEF2A
Full NameMyocyte Enhancer Factor 2A
Chromosome15q26.3.
Protein TypeTranscription Factor
FunctionMEF2A is a activity-dependent transcription factor with critical neuronal functions:
Molecular Weight55 kDa
Amino Acids507 aa
Exons13
PathwaysMAPK, MAPK pathway
UniProt IDQ02078
NCBI Gene ID4205
Ensembl IDENSG00000068305
OMIM600660
GeneCardsMEF2A
Human Protein AtlasMEF2A
Associated DiseasesAging
InteractionsAGING, AMPK, AND, AQP1, CAMKII, DNA
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (4)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: inhibits
AQP1 Gene
gene · KG edge: inhibits
HDAC4 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

HDAC4 inhibits MEF2A
MEF2A inhibits AQP1
MEF2A inhibits HDAC4
AQP1 inhibits MEF2A
AQP1 regulates MEF2A
HDAC4 regulates MEF2A
MEF2A therapeutic_target Senescence
MEF2A inhibits Aging
MEF2A inhibits Ms
MEF2A therapeutic_target Cardiovascular

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