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mechanism 1,518 words KG: HIPPO
Contents

Hippo Signaling in 4R-Tauopathies

⚙ Mechanism Info
NameHIPPO
Key Genes/ProteinsABCB1, ACSL4, Actin, AGING, AKT, ALS
Related DiseasesAddiction, Aging, Als, Alzheimer
Related PathwaysAkt, Amyloid

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Related Hypotheses (175)

Purinergic P2Y12 Inverse Agonist Therapy
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Score: 0.68...
Score: 0.68Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67Glial Glycocalyx Remodeling Therapy
Score: 0.65Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64Vagal Afferent Microbial Signal Modulation
Score: 0.62TREM2-mediated microglial tau clearance enhancement
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Score: 0.61
← Prevpg 2/9Next →

Related Analyses (30)

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neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (8)

Silibinin-induced G2/M cell cycle arrest in breast cancer ce
exploratory · proposed · Score: 0.90Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90Direct targeting of Capza1 by silibinin
exploratory · proposed · Score: 0.85Microtubule domain analysis in adult axons
exploratory · proposed · Score: 0.80Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40

See Also (12)

ATP P2X3 Receptor Neurons
cell · KG edge: activatesAmyotrophic Lateral Sclerosis
redirect · KG edge: expressed_inAMPK (AMP-Activated Protein Kinase)
entity · KG edge: activatesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: activates

Knowledge Graph (12 edges)

MPXV regulates HIPPO
HIPPO associated_with STAT3
MTOR regulates HIPPO
HIPPO therapeutic_target P53
HIPPO therapeutic_target INFLAMMATION
HIPPO therapeutic_target AUTOPHAGY
HIPPO therapeutic_target OXIDATIVE STRESS
HIPPO therapeutic_target INSULIN RESISTANCE
HIPPO therapeutic_target FOXO1
HIPPO regulates Carcinoma

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