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mechanism 1,627 words KG: PSP
Contents

Heat Shock Protein Dysfunction in Progressive Supranuclear Palsy

⚙ Mechanism Info
NamePSP
Key Genes/ProteinsABCA7, Actin, AGING, AKT, ALZHEIMER, ALZHEIMER DISEASE
Related DiseasesAging, Als, ALS, Alzheimer, Alzheimer's disease
Related PathwaysAkt, Amyloid

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Related Hypotheses (34)

Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Low Complexity Domain Cross-Linking Inhibition
Score: 0.62Synaptic Vesicle Tau Capture Inhibition
Score: 0.58HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.58HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
← Prevpg 2/2

Related Analyses (30)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedCell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived

Related Experiments (30)

Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40Tau Pathology Initiation Zone Identification
clinical · proposed · Score: 0.40Tau Spreading Network Mapping via Spatial Transcriptomics in
clinical · proposed · Score: 0.40PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.40Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40

See Also (11)

Amyotrophic Lateral Sclerosis
redirect · KG edge: expressed_inFrontotemporal Dementia (FTD)
disease · KG edge: associated_withApoptosis in Neurodegeneration
entity · KG edge: associated_withAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: therapeutic_targetGenes
index · KG edge: activates

Knowledge Graph (12 edges)

DUSP10 associated_with PSP
MAP1S associated_with PSP
PSP associated_with SP1
PSP associated_with APOE
PSP associated_with TAU
PSP associated_with KIF13A
PSP associated_with TRIM24
PSP associated_with STX6
PSP associated_with MAPT
TAU activates PSP

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