| Gene Symbol | ZCWPW1 |
| Full Name | Zinc Finger CW-Type and PWWP Domain Containing 1 |
| Aliases | Zinc Finger CW-Type and PWWP Domain |
| Function | ZCWPW1 is a 541 amino acid protein containing CW-type and PWWP domains, which are known to bind to modified histones and participate in chromatin remodeling and gene regulation.[2] |
| Primary Expression | Moderate expression in brain and peripheral tissues |
| Molecular Weight | 61 kDa |
| Amino Acids | 541 aa |
| UniProt ID | ZCWPW1 |
| Ensembl ID | ENSG00000060337 |
| GeneCards | ZCWPW1 |
| Human Protein Atlas | ZCWPW1 |
| Chromatin Binding | The CW and PWWP domains recognize specific histone modifications, particularly H3K4me3 and H3K36me3. |
| Epigenetic Regulation | May function as a reader of histone marks and recruit chromatin-modifying complexes. |
| Gene Expression | Involved in transcriptional regulation through chromatin interactions. |
| DNA Repair | Impaired DNA repair is a feature of AD neurons; ZCWPW1 may play a role in neuronal DNA damage response. |
| Associated Diseases | Als, Alzheimer, Atherosclerosis, Dementia, Macular Degeneration |
| Interactions | ABCA7, ALZHEIMER, ALZHEIMER'S DISEASE, APOE, App, BIN1 |
| KG Connections | 146 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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