gene 1,035 words KG: VEGF
Contents

VEGF (Vascular Endothelial Growth Factor)

🧬 Gene Info
Gene SymbolVEGF
AliasesVascular Endothelial Growth Factor
FunctionVEGF serves multiple physiological functions
Primary Expressionhippocampus, motor cortex, cerebellum, cortex, striatum
PathwaysAkt, Amyloid, Apoptosis, Complement, Epigenetic
UniProt ID[P15692](https://www.uniprot.org/uniprot/P15692)
NCBI Gene ID7422
GeneCardsVEGF
Human Protein AtlasVEGF
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compoundsbevacizumab, levodopa, LEVODOPA, QUERCETIN, rapamycin, RAPAMYCIN
InteractionsAB, ACHE, AD, AGING, AHR, AKT
SciDEX HypothesesVEGF-family genetic control of vascular-neuronal c
KG Connections1548 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (37)

Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Vocal Cord Neuroplasticity Stimulation
Score: 0.52
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47
← Prevpg 2/2

Related Analyses (14)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (4)

Irisin treatment in mouse femur fracture healing model
validation · proposed · Score: 0.90
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40
Vascular Contribution to Alzheimer's Disease — Beyond Amyloi
validation · proposed · Score: 0.40

See Also (4)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates

Knowledge Graph (12 edges)

VEGF contributes_to POEMS_SYNDROME
BMP2 activates VEGF
VEGF activates FGF2
VEGF activates ANGPT1
VEGF activates PDGFRB
VEGF activates VEGFB
VEGF expressed_in TNF
VEGF associated_with BAX
VEGF associated_with FIS1
VEGF associated_with CHOP

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