gene 779 words KG: TRPV4
Contents

TRPV4 Gene

🧬 Gene Info
Gene SymbolTRPV4
Full NameTransient Receptor Potential Cation Channel Subfamily V Member 4
Chromosome12q24.11.
Protein TypeChannel
Functionof 871 amino acids with a molecular weight of approximately 98 kDa
Primary ExpressionCerebral cortex, Hippocampus, Dorsal root ganglion, Peripheral nerves, Endothelial cells
Molecular Weight98 kDa
Amino Acids871 aa
Exons15
PathwaysAkt, Angiogenesis, Blood-Brain Barrier, Er Stress, Mitophagy
UniProt IDQ9HBA0
NCBI Gene ID59341
Ensembl IDENSG00000167799
OMIM605067
GeneCardsTRPV4
Human Protein AtlasTRPV4
Associated DiseasesAging, Als, Alzheimer, Blood-CNS Barrier Disruption, Cancer
Known Drugs/Compoundscannabidiol, CBD
InteractionsAKT, AMPK, AND, ATF4, CANCER, Cytokine
KG Connections303 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (10)

Extracellular Matrix Stiffness Modulation
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.92
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Aquaporin-4 Polarization Rescue
Score: 0.73
Purinergic Signaling Polarization Control
Score: 0.71

Related Analyses (7)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

DEX effects on K2P channel transcriptome in mouse TM cells
exploratory · proposed · Score: 0.90

See Also (9)

Striatal Interneurons in Corticobasal Degeneration
cell · KG edge: activates
blarcamesine-axon
clinical_trial · KG edge: associated_with
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: expressed_in
AQP4 (Aquaporin-4 Gene)
gene · KG edge: expressed_in
ATF4 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PIEZO1 expressed_in TRPV4
KCNK2 associated_with TRPV4
SCN5A associated_with TRPV4
TRPM7 associated_with TRPV4
SCN1A associated_with TRPV4
TRPV4 associated_with CACNA1B
TRPV4 associated_with SCNN1A
TRPV4 associated_with CFTR
TRPV4 associated_with PIEZO2
TRPV4 associated_with TRPA1

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