Clinical experiment designed to assess clinical efficacy targeting TLR2, TLR4 in human patients. Primary outcome: TLR2 and TLR4 expression levels in blood and brain
Flow cytometry and western blot analysis were performed to detect toll-like receptor 2 and 4 expression in blood and brain samples from Parkinson's disease patients. The study examined circulating monocytes and B cells in blood samples, as well as brain tissue from the caudate/putamen region. Results showed increased TLR2 and TLR4 expression in circulating monocytes, increased TLR4 in B cells, and increased TLR4 in the caudate/putamen of Parkinson's disease patients compared to controls. This clinical study provides evidence for immune system activation and toll-like receptor upregulation in Parkinson's disease patients, supporting the hypothesis that inflammation contributes to disease pathogenesis.
Flow cytometry and western blot analysis of blood samples (monocytes, B cells) and brain tissue (caudate/putamen)
Increased TLR expression in Parkinson's disease patients
Significant increase in TLR2/TLR4 expression compared to controls
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