| Gene Symbol | OPRM1 |
| Full Name | Mu-Opioid Receptor |
| Protein Type | Protein |
| Function | is a G protein-coupled receptor (GPCR) primarily known for its role in pain modulation, reward processing, and opioid drug responses[@minami1995]. |
| Pathways | autophagy pathway |
| UniProt ID | Search UniProt |
| GeneCards | OPRM1 |
| Human Protein Atlas | OPRM1 |
| Seven transmembrane domains (TM1-TM7) | Classic GPCR architecture spanning the neuronal membrane |
| Extracellular loops (ECL1-ECL3) | Form the ligand binding interface for endogenous and exogenous opioids |
| Intracellular loops (ICL1-ICL3) | Facilitate G protein coupling and downstream signaling cascades |
| C-terminal tail | Contains phosphorylation sites for arrestin binding and receptor desensitization[@filizola2005] |
| N-glycosylation | Extracellular N-linked glycosylation affects receptor trafficking and ligand binding |
| Palmitoylation | C-terminal palmitoylation anchors the receptor in the membrane |
| Phosphorylation | Serine and threonine residues phosphorylated by GRK kinases[@feng2006] |
| Associated Diseases | Addiction, Alzheimer, Alzheimer's disease, Anxiety, Dementia |
| Interactions | BDNF, DRD2, DRD4, GENES, OPRD1, PER |
| KG Connections | 100 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!