| Gene Symbol | RANK (TNFRSF11A) |
| Full Name | TNF Receptor Superfamily Member 11A |
| Aliases | TNFRSF11A |
| Chromosome | 18q21.33 |
| Protein Type | Receptor |
| Function | RANK is a type I transmembrane protein expressed primarily on osteoclast precursors, dendritic cells, and activated T cells[@anderson1997]. |
| Pathways | NF-κB |
| UniProt ID | Q9Y275 |
| NCBI Gene ID | 26986 |
| Ensembl ID | ENSG00000141655 |
| OMIM | 603799 |
| Osteoclast Differentiation | RANKL binding activates NF-κB, c-Fos, and NFATc1 signaling cascades that drive osteoclast precursor cells to mature, functional osteoclasts[@hsu1999] |
| Bone Remodeling | The RANK/RANKL/OPG axis is the primary regulator of bone resorption and formation balance |
| Calcium Homeostasis | Through osteoclast activity, RANK signaling indirectly regulates serum calcium levels |
| Dendritic Cell Survival | RANK signaling promotes dendritic cell survival and maturation, essential for antigen presentation[@josien1999] |
| Associated Diseases | Aging, Als, Autoimmune, Cancer, Hypertension |
| Interactions | Actin, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND |
| KG Connections | 408 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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