gene 2,588 words KG: E2F7
Contents

E2F7 Gene

🧬 Gene Info
Gene SymbolE2F7
AliasesE2F transcription factor 7
Chromosome12q21.2
Protein TypeTranscription Factor
Functionencodes an atypical E2F transcription factor that functions primarily as a transcriptional repressor.
Molecular Weight90 kDa
Amino Acids816 aa
PathwaysCell Cycle
GeneCardsE2F7
Human Protein AtlasE2F7
BrainHigh expression in developing and adult neurons, particularly in the cortex and hippocampus
Proliferating cellsElevated in actively dividing cells
Germline tissuesModerate expression in testis and ovary
Mature organsLower expression in most adult tissues with notable exceptions
Associated Diseasesneurodegeneration
InteractionsAND, CANCER, E2F1, E2F2, E2F3, E2F8
KG Connections41 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
APOE-Dependent Autophagy Restoration
Score: 0.85
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

E2F regulation of endocycles in hepatocytes
validation · proposed · Score: 0.85
E2F coordination of G2/M transcriptional program
exploratory · proposed · Score: 0.75
E2F regulation of endocycles in trophoblast giant cells
validation · proposed · Score: 0.85

See Also (7)

DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: regulates
Genes
index · KG edge: inhibits
E2F1 Gene
gene · KG edge: activates
E2F Transcription Factor 2
gene · KG edge: activates
E2F3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

E2F7 activates E2F8
E2F7 activates E2F1
E2F7 activates E2F2
E2F7 activates E2F3
E2F8 activates E2F7
E2F1 activates E2F7
E2F2 activates E2F7
E2F3 activates E2F7
TP53 inhibits E2F7
E2F7 interacts_with RB1

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