gene 1,504 words KG: RAB5
Contents

RAB5A Gene

🧬 Gene Info
Gene SymbolRAB5A
Full NameRAB5A, member RAS oncogene family
Chromosome3p24.3
Functionencodes a critical small GTPase that serves as the master regulator of early endosome function.
Molecular Weight23.5 kDa
Amino Acids218 aa
PathwaysApoptosis, Autophagy, Endocytosis, Mitophagy, VESICLE_TRAFFICKING
UniProt IDP20339
NCBI Gene ID5868
Ensembl IDENSG00000112984
OMIM171585
GeneCardsRAB5A
Human Protein AtlasRAB5A
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia, Dementia
InteractionsAlbumin, ALS2, AND, ARHGEF7, ATG, ATG9A
KG Connections389 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (30)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
SASP-Mediated Complement Cascade Amplification
Score: 0.91
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.85
APOE-Dependent Autophagy Restoration
Score: 0.85

Related Analyses (12)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (5)

Amyotrophic Lateral Sclerosis
redirect · KG edge: causes
ALS2 (Alsin)
gene · KG edge: causes
Alzheimer Indonesia
institution · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

RAB5 regulates VESICLE_TRAFFICKING
RAB5 inhibits neurodegeneration
ELAVL2 therapeutic_target RAB5
C1Q inhibits RAB5
MTOR therapeutic_target RAB5
CLPP therapeutic_target RAB5
RAB11 inhibits RAB5
STX17 therapeutic_target RAB5
RAB5 therapeutic_target SNAP29
RAB5 therapeutic_target IGF2BP1

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