Contents

GCLM — Glutamate-Cysteine Ligase Modifier Subunit

🧬 Gene Info

Gene Symbol	GCLM
Full Name	Glutamate-Cysteine Ligase Modifier Subunit
Chromosome	1p22.1
Function	GCLM forms a heterodimer with GCLC (glutamate-cysteine ligase catalytic subunit) to create functional glutamate-cysteine ligase.
Primary Expression	Liver, Kidney, Brain, Lung
Molecular Weight	31 kDa
Amino Acids	274 aa
Pathways	oxidative stress response
UniProt ID	P48507
NCBI Gene ID	2739
Ensembl ID	ENSG00000100916
OMIM	606466
GeneCards	GCLM
Human Protein Atlas	GCLM
Associated Diseases	Infection, Inflammation, Sepsis
Interactions	GCLC, NRF2
KG Connections	53 knowledge graph edges
Databases	GeneCards HPA STRING

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